| pubmed-article:8967361 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8967361 | lifeskim:mentions | umls-concept:C0001675 | lld:lifeskim |
| pubmed-article:8967361 | lifeskim:mentions | umls-concept:C0325089 | lld:lifeskim |
| pubmed-article:8967361 | lifeskim:mentions | umls-concept:C0225828 | lld:lifeskim |
| pubmed-article:8967361 | lifeskim:mentions | umls-concept:C0256926 | lld:lifeskim |
| pubmed-article:8967361 | lifeskim:mentions | umls-concept:C0333516 | lld:lifeskim |
| pubmed-article:8967361 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:8967361 | lifeskim:mentions | umls-concept:C2347040 | lld:lifeskim |
| pubmed-article:8967361 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:8967361 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:8967361 | pubmed:issue | 4 Pt 2 | lld:pubmed |
| pubmed-article:8967361 | pubmed:dateCreated | 1996-12-4 | lld:pubmed |
| pubmed-article:8967361 | pubmed:abstractText | Tumor necrosis factor-alpha (TNF-alpha) is a proinflammatory cytokine that is elaborated in a myriad of cardiac disease states. Although the biological role for TNF-alpha in the adult heart is not known, a recent study in fetal myocardial cells has shown that this cytokine increases the synthesis of low-molecular-weight stress proteins. These findings suggested the interesting possibility that TNF-alpha might play a functional role in the adult heart by increasing the expression of stress proteins in cardiac myocytes. Accordingly, the purpose of this study was to determine whether TNF-alpha would modulate the expression of heat shock protein 72 (HSP 72), a stress protein that is thought to exert protective effects in the adult heart. Stimulation of adult feline cardiac myocytes with a range of TNF-alpha concentrations (10-1,000 U/ml) for 12 h showed that concentrations of TNF-alpha < or = 10 U/ml had no effect on HSP 72 expression: increased HSP 72 expression was detected 3 h following cytokine stimulation, peaked by approximately 12 h, and then returned toward baseline by 48 h. Additional studies indicated that stimulation of the type 1 TNF receptor was responsible for the increase in HSP 72 expression. In summary, these studies constitute the initial demonstration that TNF-alpha exerts concentration- and time-dependent effects on the expression of HSP 72 in the adult mammalian cardiac myocytes, thus suggesting the interesting possibility that the elaboration of TNF-alpha may enable the heart to better withstand certain forms of stress. | lld:pubmed |
| pubmed-article:8967361 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8967361 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8967361 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8967361 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8967361 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8967361 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8967361 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8967361 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8967361 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:8967361 | pubmed:issn | 0002-9513 | lld:pubmed |
| pubmed-article:8967361 | pubmed:author | pubmed-author:NakanoMM | lld:pubmed |
| pubmed-article:8967361 | pubmed:author | pubmed-author:PILZCC | lld:pubmed |
| pubmed-article:8967361 | pubmed:author | pubmed-author:YokoyamaTT | lld:pubmed |
| pubmed-article:8967361 | pubmed:author | pubmed-author:LesslauerWW | lld:pubmed |
| pubmed-article:8967361 | pubmed:author | pubmed-author:KnowltonA AAA | lld:pubmed |
| pubmed-article:8967361 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8967361 | pubmed:volume | 270 | lld:pubmed |
| pubmed-article:8967361 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8967361 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8967361 | pubmed:pagination | H1231-9 | lld:pubmed |
| pubmed-article:8967361 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:8967361 | pubmed:meshHeading | pubmed-meshheading:8967361-... | lld:pubmed |
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| pubmed-article:8967361 | pubmed:meshHeading | pubmed-meshheading:8967361-... | lld:pubmed |
| pubmed-article:8967361 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8967361 | pubmed:articleTitle | Tumor necrosis factor-alpha-induced expression of heat shock protein 72 in adult feline cardiac myocytes. | lld:pubmed |
| pubmed-article:8967361 | pubmed:affiliation | Department of Medicine, Veterans Affairs Medical Center, Houston, Texas, USA. | lld:pubmed |
| pubmed-article:8967361 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8967361 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8967361 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
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