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pubmed-article:8965166pubmed:abstractTextSingle-chain Fv (scFv) antibody fragments have potential for clinical imaging because of their rapid tumor penetration and high tumor-to-tissue ratios at early time points. ScFvs clear rapidly from the circulation so radiolabels such as 99mTc which have short half-lives are desirable, but the free thiol groups necessary for labeling with 99mTc are not normally found on these molecules.lld:pubmed
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pubmed-article:8965166pubmed:articleTitleTechnetium-99m radiolabeling using a phage-derived single-chain Fv with a C-terminal cysteine.lld:pubmed
pubmed-article:8965166pubmed:affiliationCRC Laboratories, Department of Clinical Oncology, Royal Free Hospital School of Medicine, London, United Kingdom.lld:pubmed
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