|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
1996-12-11
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|
pubmed:abstractText |
Single-chain Fv (scFv) antibody fragments have potential for clinical imaging because of their rapid tumor penetration and high tumor-to-tissue ratios at early time points. ScFvs clear rapidly from the circulation so radiolabels such as 99mTc which have short half-lives are desirable, but the free thiol groups necessary for labeling with 99mTc are not normally found on these molecules.
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|
pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
|
|
pubmed:issn |
0161-5505
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
37
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
868-72
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:8965166-Adenocarcinoma,
pubmed-meshheading:8965166-Animals,
pubmed-meshheading:8965166-Colonic Neoplasms,
pubmed-meshheading:8965166-Humans,
pubmed-meshheading:8965166-Immunoglobulin Fragments,
pubmed-meshheading:8965166-Isotope Labeling,
pubmed-meshheading:8965166-Mice,
pubmed-meshheading:8965166-Neoplasm Transplantation,
pubmed-meshheading:8965166-Radioimmunodetection,
pubmed-meshheading:8965166-Technetium,
pubmed-meshheading:8965166-Tissue Distribution,
pubmed-meshheading:8965166-Transplantation, Heterologous,
pubmed-meshheading:8965166-Tumor Cells, Cultured
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|
pubmed:year |
1996
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|
pubmed:articleTitle |
Technetium-99m radiolabeling using a phage-derived single-chain Fv with a C-terminal cysteine.
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|
pubmed:affiliation |
CRC Laboratories, Department of Clinical Oncology, Royal Free Hospital School of Medicine, London, United Kingdom.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
