Linked Life Data

8964743

Source:http://linkedlifedata.com/resource/pubmed/id/8964743

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1996-12-3
pubmed:abstractText
Although skeletal muscle (SM) is a major body component, whole body measurement methods remain limited and inadequately investigated. The aim of the present study was to evaluate the Burkinshaw in vivo neutron activation analysis (IVNA)-whole body 40K-counting and dual-energy X-ray absorptiometry (DXA) methods of estimating SM by comparison to adipose tissue-free SM measured using multiscan computerized axial tomography (CT). In the Burkinshaw method the potassium-to-nitrogen ratios of SM and non-SM lean tissue are assumed constant; in the DXA method the ratio of appendicular SM to total SM is assumed constant at 0.75. Seventeen healthy men [77.5 +/- 13.8 (SD) kg body wt] and eight men with acquired immunodeficiency syndrome (AIDS; 65.5 +/- 7.6 kg) completed CT, IVNA, and DXA studies. SM measured by CT was 34.4 +/- 6.2 kg for the healthy subjects and 27.2 +/- 4.0 kg for the AIDS patients. Compared with CT, the Burkinshaw method underestimated SM by an average of 6.9 kg (20.1%, P = 0.0001) and 6.3 kg (23.2%, P = 0.01) in the healthy men and the men with AIDS, respectively. The DXA method minimally overestimated SM in both groups (2.0 kg and 5.8% in healthy men, P = 0.001; 1.4 kg and 5.1% in men with AIDS, P = 0.16). This overestimate could be explained by a higher actual than assumed ratio of DXA-measured appendicular SM to total body SM (actual = 0.79 +/- 0.05, assumed = 0.75). The current study results reveal that large errors are present in the Burkinshaw SM method and that substantial refinements in the models that form the basis of this IVNA approach are needed. The model on which the DXA-SM method is based also needs further minor refinements, but this is a promising in vivo approach because of less radiation exposure and lower cost than the IVNA and CT methods.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
8750-7587
pubmed:author
pubmed:issnType
Print
pubmed:volume
80
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
824-31
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Skeletal muscle mass: evaluation of neutron activation and dual-energy X-ray absorptiometry methods.
pubmed:affiliation
Obesity Research Center, St. Luke's-Roosevelt Hospital, College of Physicians and Surgeons, Columbia University, New York 10025, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.