Linked Life Data

8964578

Source:http://linkedlifedata.com/resource/pubmed/id/8964578

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3-5
pubmed:dateCreated
1996-12-12
pubmed:abstractText
Gene targeting provides a direct method for introducing mutations into specific mouse loci. This approach has been used productively to demonstrate that insulin-like growth factor (IGF) peptides and receptors are required for normal prenatal growth. Six genes comprising a third major component of the IGF system, the IGF-binding proteins (IGFBPs), are all expressed during prenatal rodent development. One of these genes, IGFBP-2, has also been disrupted using gene targeting, and homozygous null BP-2 mice are characterized by a decreased spleen size and an increase in circulating levels of other IGFBPs. These alterations are less dramatic than initially expected based on the fetal IGFBP-2 expression pattern. These results are discussed in light of both other genetic ablations involving members of gene families and in the context of the expression of other IGFBPs in rodent fetal and uterine tissues.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0301-0163
pubmed:author
pubmed:issnType
Print
pubmed:volume
45
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
172-7
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Genetic approaches to the function of insulin-like growth factor-binding proteins during rodent development.
pubmed:affiliation
Department of Neuroscience and Cell Biology UMDNJ-Robert Wood Johnson Medical School, Piscataway 08854 USA.
pubmed:publicationType
Journal Article, Review