rdf:type |
|
lifeskim:mentions |
umls-concept:C0003250,
umls-concept:C0006556,
umls-concept:C0009015,
umls-concept:C0009219,
umls-concept:C0023693,
umls-concept:C0032105,
umls-concept:C0085201,
umls-concept:C0086418,
umls-concept:C0205369,
umls-concept:C0439539,
umls-concept:C1524075,
umls-concept:C1880022
|
pubmed:issue |
2
|
pubmed:dateCreated |
1996-12-4
|
pubmed:databankReference |
|
pubmed:abstractText |
We have determined the nucleotide (nt) sequences encoding the heavy (H)- and light (L)-chains of the Fab fragment of a murine monoclonal antibody, MabA34 (gamma1, kappa), which is specific for human plasma apolipoprotein A-I of high-density lipoproteins. The variable (V) regions of the H- and L-chains were revealed to be members of mouse H-chain subgroup II(A) and kappa L-chain subgroup II, respectively. A few unusual amino acids in the V region of the H-chain, and nt residues probably introduced by somatic mutations from germline genes were also identified.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Sep
|
pubmed:issn |
0378-1119
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
16
|
pubmed:volume |
173
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
257-9
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:8964510-Amino Acid Sequence,
pubmed-meshheading:8964510-Animals,
pubmed-meshheading:8964510-Antibodies, Monoclonal,
pubmed-meshheading:8964510-Apolipoprotein A-I,
pubmed-meshheading:8964510-Base Sequence,
pubmed-meshheading:8964510-Cloning, Molecular,
pubmed-meshheading:8964510-DNA, Complementary,
pubmed-meshheading:8964510-Humans,
pubmed-meshheading:8964510-Hybridomas,
pubmed-meshheading:8964510-Immunoglobulin Fab Fragments,
pubmed-meshheading:8964510-Immunoglobulin Heavy Chains,
pubmed-meshheading:8964510-Immunoglobulin Light Chains,
pubmed-meshheading:8964510-Mice,
pubmed-meshheading:8964510-Mice, Inbred BALB C,
pubmed-meshheading:8964510-Molecular Sequence Data
|
pubmed:year |
1996
|
pubmed:articleTitle |
Cloning and characterization of cDNAs coding for heavy and light chains of a monoclonal antibody (MabA34) specific for human plasma apolipoprotein A-I.
|
pubmed:affiliation |
Korea Research Institute of Bioscience and Biotechnology, KIST, Daeduck Science Town, Taejon, South Korea.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|