| pubmed-article:8960826 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8960826 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:8960826 | lifeskim:mentions | umls-concept:C0011860 | lld:lifeskim |
| pubmed-article:8960826 | lifeskim:mentions | umls-concept:C0033621 | lld:lifeskim |
| pubmed-article:8960826 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:8960826 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:8960826 | pubmed:dateCreated | 1997-3-28 | lld:pubmed |
| pubmed-article:8960826 | pubmed:abstractText | Enhanced activation of the clotting system has been recently implicated in the pathogenesis of vascular complications in patients with diabetes mellitus. Abnormalities of the anticoagulant system may constitute a potential trigger factor for the haemostatic activation observed in diabetic subjects. The current study aimed to evaluate anticoagulant activity in diabetic patients by assessing the plasma levels of activated protein C-protein C inhibitor complex; and by measuring the anticoagulant response to exogenous thrombomodulin. This study comprised 61 patients (34 men, 27 women) with non-insulin-dependent diabetes mellitus (NIDDM) of whom 22 showed microalbuminuria and 39 normoalbuminuria. Data obtained in 31 non-obese and non-diabetic subjects were available for comparison. The plasma levels of fibrinogen (p < 0.02), prothrombin fragment 1 + 2 (p < 0.05), fibrin monomer (p < 0.0001), protein C antigen (p < 0.005), total protein S antigen (p < 0.02), soluble thrombomodulin (p < 0.005) and soluble E-selectin (p < 0.005) were significantly higher in diabetic patients than in healthy subjects. The plasma level of activated protein C-protein C inhibitor complex (7.4 +/- 3.8 vs 3.0 +/- 0.4 pmol/l) was significantly higher (p < 0.0001) and the anticoagulant response to exogenous thrombomodulin (23.4 +/- 2.6 vs 35.3 +/- 3.0 ng/ml) was markedly lower (p = 0.005) in all diabetic patients than in healthy subjects. Cases with microalbuminuria presented low plasma levels of activated protein C-protein C inhibitor complex (5.5 +/- 0.6 vs 8.6 +/- 0.7 pmol/l, p < 0.05) and significantly decreased values of the anticoagulant response to exogenous thrombomodulin (16.5 +/- 2.9 vs 23.4 +/- 2.6%, p = 0.03) as compared to those with normoalbuminuria. The present study suggests that the hyper-coagulable state in NIDDM is associated with an increased activation of protein C but with a poor plasma reactivity to the anticoagulant effect of thrombomodulin. | lld:pubmed |
| pubmed-article:8960826 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8960826 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8960826 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8960826 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8960826 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8960826 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8960826 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8960826 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8960826 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8960826 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8960826 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8960826 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8960826 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8960826 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:8960826 | pubmed:issn | 0012-186X | lld:pubmed |
| pubmed-article:8960826 | pubmed:author | pubmed-author:SuzukiKK | lld:pubmed |
| pubmed-article:8960826 | pubmed:author | pubmed-author:NakataniKK | lld:pubmed |
| pubmed-article:8960826 | pubmed:author | pubmed-author:ShimaTT | lld:pubmed |
| pubmed-article:8960826 | pubmed:author | pubmed-author:MurataKK | lld:pubmed |
| pubmed-article:8960826 | pubmed:author | pubmed-author:SataMM | lld:pubmed |
| pubmed-article:8960826 | pubmed:author | pubmed-author:NishiokaJJ | lld:pubmed |
| pubmed-article:8960826 | pubmed:author | pubmed-author:YanoYY | lld:pubmed |
| pubmed-article:8960826 | pubmed:author | pubmed-author:TaguchiOO | lld:pubmed |
| pubmed-article:8960826 | pubmed:author | pubmed-author:SumidaYY | lld:pubmed |
| pubmed-article:8960826 | pubmed:author | pubmed-author:DeguchiHH | lld:pubmed |
| pubmed-article:8960826 | pubmed:author | pubmed-author:MohriMM | lld:pubmed |
| pubmed-article:8960826 | pubmed:author | pubmed-author:TakeyaHH | lld:pubmed |
| pubmed-article:8960826 | pubmed:author | pubmed-author:GabazzaE CEC | lld:pubmed |
| pubmed-article:8960826 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8960826 | pubmed:volume | 39 | lld:pubmed |
| pubmed-article:8960826 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8960826 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8960826 | pubmed:pagination | 1455-61 | lld:pubmed |
| pubmed-article:8960826 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:8960826 | pubmed:meshHeading | pubmed-meshheading:8960826-... | lld:pubmed |
| pubmed-article:8960826 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8960826 | pubmed:articleTitle | Protein C activation in NIDDM patients. | lld:pubmed |
| pubmed-article:8960826 | pubmed:affiliation | Department of Molecular Pathobiology, Mie University School of Medicine, Japan. | lld:pubmed |
| pubmed-article:8960826 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8960826 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:8960826 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8960826 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8960826 | lld:pubmed |
