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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
12
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pubmed:dateCreated |
1997-3-28
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pubmed:abstractText |
Enhanced activation of the clotting system has been recently implicated in the pathogenesis of vascular complications in patients with diabetes mellitus. Abnormalities of the anticoagulant system may constitute a potential trigger factor for the haemostatic activation observed in diabetic subjects. The current study aimed to evaluate anticoagulant activity in diabetic patients by assessing the plasma levels of activated protein C-protein C inhibitor complex; and by measuring the anticoagulant response to exogenous thrombomodulin. This study comprised 61 patients (34 men, 27 women) with non-insulin-dependent diabetes mellitus (NIDDM) of whom 22 showed microalbuminuria and 39 normoalbuminuria. Data obtained in 31 non-obese and non-diabetic subjects were available for comparison. The plasma levels of fibrinogen (p < 0.02), prothrombin fragment 1 + 2 (p < 0.05), fibrin monomer (p < 0.0001), protein C antigen (p < 0.005), total protein S antigen (p < 0.02), soluble thrombomodulin (p < 0.005) and soluble E-selectin (p < 0.005) were significantly higher in diabetic patients than in healthy subjects. The plasma level of activated protein C-protein C inhibitor complex (7.4 +/- 3.8 vs 3.0 +/- 0.4 pmol/l) was significantly higher (p < 0.0001) and the anticoagulant response to exogenous thrombomodulin (23.4 +/- 2.6 vs 35.3 +/- 3.0 ng/ml) was markedly lower (p = 0.005) in all diabetic patients than in healthy subjects. Cases with microalbuminuria presented low plasma levels of activated protein C-protein C inhibitor complex (5.5 +/- 0.6 vs 8.6 +/- 0.7 pmol/l, p < 0.05) and significantly decreased values of the anticoagulant response to exogenous thrombomodulin (16.5 +/- 2.9 vs 23.4 +/- 2.6%, p = 0.03) as compared to those with normoalbuminuria. The present study suggests that the hyper-coagulable state in NIDDM is associated with an increased activation of protein C but with a poor plasma reactivity to the anticoagulant effect of thrombomodulin.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/E-Selectin,
http://linkedlifedata.com/resource/pubmed/chemical/Fibrinogen,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Protein C,
http://linkedlifedata.com/resource/pubmed/chemical/Protein C Inhibitor,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Precursors,
http://linkedlifedata.com/resource/pubmed/chemical/Prothrombin,
http://linkedlifedata.com/resource/pubmed/chemical/Thrombomodulin,
http://linkedlifedata.com/resource/pubmed/chemical/prothrombin fragment 1,
http://linkedlifedata.com/resource/pubmed/chemical/prothrombin fragment 2
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0012-186X
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pubmed:author |
pubmed-author:DeguchiHH,
pubmed-author:GabazzaE CEC,
pubmed-author:MohriMM,
pubmed-author:MurataKK,
pubmed-author:NakataniKK,
pubmed-author:NishiokaJJ,
pubmed-author:SataMM,
pubmed-author:ShimaTT,
pubmed-author:SumidaYY,
pubmed-author:SuzukiKK,
pubmed-author:TaguchiOO,
pubmed-author:TakeyaHH,
pubmed-author:YanoYY
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pubmed:issnType |
Print
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pubmed:volume |
39
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1455-61
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8960826-Adult,
pubmed-meshheading:8960826-Aged,
pubmed-meshheading:8960826-Blood Coagulation,
pubmed-meshheading:8960826-Cohort Studies,
pubmed-meshheading:8960826-Diabetes Mellitus, Type 2,
pubmed-meshheading:8960826-E-Selectin,
pubmed-meshheading:8960826-Enzyme Activation,
pubmed-meshheading:8960826-Female,
pubmed-meshheading:8960826-Fibrinogen,
pubmed-meshheading:8960826-Humans,
pubmed-meshheading:8960826-Male,
pubmed-meshheading:8960826-Middle Aged,
pubmed-meshheading:8960826-Peptide Fragments,
pubmed-meshheading:8960826-Protein C,
pubmed-meshheading:8960826-Protein C Inhibitor,
pubmed-meshheading:8960826-Protein Precursors,
pubmed-meshheading:8960826-Prothrombin,
pubmed-meshheading:8960826-Reference Values,
pubmed-meshheading:8960826-Thrombomodulin
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pubmed:year |
1996
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pubmed:articleTitle |
Protein C activation in NIDDM patients.
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pubmed:affiliation |
Department of Molecular Pathobiology, Mie University School of Medicine, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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