Linked Life Data

8960563

Source:http://linkedlifedata.com/resource/pubmed/id/8960563

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
25
pubmed:dateCreated
1997-1-23
pubmed:abstractText
We recently reported a novel hydrophobic descriptor for quantitative structure-activity relationship (QSAR) studies, the logarithm of the partition coefficient micelle/water (log Pmw), which is easily determined by a HPLC system and is thought to be a descriptor for a compound's affinity to a biomembrane. We carried out QSAR studies using log Pmw on the antiplatelet activities of novel fibrinogen inhibitors, [[4-(4-amidinophenoxy)butanoyl]aspartyl]valine (FK633) derivatives, which resulted in a quadratic curve with a good correlation coefficient (n = 12, s = 0.368, F = 14.1**, r = 0.871), indicating that a suitable membrane affinity of the fibrinogen inhibitors is vital for their inhibitory activities. QSAR studies using STERIMOL parameters and/or CLOGP values were unsuccessful.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0022-2623
pubmed:author
pubmed:issnType
Print
pubmed:day
6
pubmed:volume
39
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5017-20
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Quantitative structure-activity relationship study of fibrinogen inhibitors, [[4-(4-amidinophenoxy)butanoyl]aspartyl]valine (FK633) derivatives, using a novel hydrophobic descriptor.
pubmed:affiliation
Basic Research Laboratories, Fujisawa Pharmaceutical Company Ltd., Yodogawa-ku, Osaka, Japan.
pubmed:publicationType
Journal Article