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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
1997-3-12
|
| pubmed:abstractText |
The purpose of the study was to analyse patterns of DNA content in hepatocellular carcinomas (HCC) submitted to orthotopic liver transplantation (OLT). Paraffin-embedded archival material from 15 patients (ten men, five women, mean age 51 +/- 1.78 years) transplanted in St-Roch Hospital between 1988 and 1991 was available for laboratory evaluation by flow cytometry. Five out of 15 were incidental HCC. The analysis was performed by a FACSscan flow cytometer coupled to a Hewlett-Packard computer. The cellular DNA content was defined as diploid or aneuploid in the presence of a single (DNA index of 1) or two distinct (DNA index different from 1) Gzero/G1 peaks, respectively. All incidental HCC (five patients) were diploid, the tumour size was 1.2 +/- 0.2 cm, the number of nodules was 1.4 +/- 0.24 and the mortality rate was 40%. No death in the incidental HCC group was related to neoplastic recurrence. In the remaining ten patients transplanted for HCC, we observed 50% diploid tumours, the tumour size was 5.2 +/- 1.55 cm and the number of nodules was 2.7 +/- 0.56. In this group six patients died of neoplastic recurrence (two were diploid and four aneuploid). The diameter of the neoplasm in diploid patients who died of neoplastic recurrence was over 5 cm and the number of nodules was over three. Moreover, in aneuploid patients who died of neoplastic recurrence, the diameter of the neoplasm was less than 5 cm in three cases and the number of nodules was less than three in two patients. This study indicates that incidental HCC may be a less aggressive malignancy and may have a better prognosis. In this group, no patient recurred after OLT and all tumours were diploid. Aneuploidy, tumour size (> 5 cm) and number of lesions (> 3) are prognostic indicators for neoplastic recurrence in patients transplanted for hepatocellular carcinoma.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0934-0874
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
9 Suppl 1
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
S112-4
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| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:8959805-Adult,
pubmed-meshheading:8959805-Carcinoma, Hepatocellular,
pubmed-meshheading:8959805-DNA, Neoplasm,
pubmed-meshheading:8959805-Female,
pubmed-meshheading:8959805-Flow Cytometry,
pubmed-meshheading:8959805-Humans,
pubmed-meshheading:8959805-Liver Neoplasms,
pubmed-meshheading:8959805-Liver Transplantation,
pubmed-meshheading:8959805-Male,
pubmed-meshheading:8959805-Middle Aged,
pubmed-meshheading:8959805-Neoplasm Recurrence, Local,
pubmed-meshheading:8959805-Retrospective Studies
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
DNA flow cytometry in patients undergoing liver transplantation for hepatocellular carcinoma.
|
| pubmed:affiliation |
Department of Liver Transplantation, University of Sophia Antipolis, Saint-Roch Hospital, Nice, France.
|
| pubmed:publicationType |
Journal Article
|