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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
1997-3-12
|
| pubmed:abstractText |
To investigate the effect of cytomegalovirus (CMV) infection on the development of experimental chronic kidney allograft rejection, orthotopic kidney allografts from DA donors (Ag-B4, RT1a1) to WF (Ag-B2, RT1u) recipients were used. The rats received cyclosporine A (CsA) for 12 weeks. A group of recipients was infected with 10(5) plaque-forming units of rat CMV (RCMV), and another group was left non-infected and used as controls. The grafts were removed 12 weeks after transplantation. RCMV infection significantly enhanced the development of chronic kidney allograft rejection as follows: the intensity of interstitial inflammation (P < 0.025), particularly the degree of pyroninophilic cells in the inflammatory infiltrate (P < 0.025); the glomeruli mesangial matrix increase (P < 0.05) and capillary basement membrane thickening (P < 0.01); the extent of endothelial cell swelling (P < 0.025) and intimal proliferation (P < 0.025) in the graft vasculature; and the extent of tubular epithelial atrophy (P < 0.025). The chronic allograft damage index (CADI) was significantly increased to 4.2 +/- 0.9 in RCMV-infected allografts, compared with 0.8 +/- 0.4 in non-infected (P < 0.02). At the molecular level, RCMV infection significantly increased vascular endothelial (P < 0.05) and tubular epithelial (P < 0.01) ICAM-1 expression. Viral antigens were detected in tubular epithelial cells and in some inflammatory cells.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0934-0874
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
9 Suppl 1
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
S3-4
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:8959777-Animals,
pubmed-meshheading:8959777-Chronic Disease,
pubmed-meshheading:8959777-Cytomegalovirus Infections,
pubmed-meshheading:8959777-Graft Rejection,
pubmed-meshheading:8959777-Kidney Transplantation,
pubmed-meshheading:8959777-Rats,
pubmed-meshheading:8959777-Rats, Inbred WF,
pubmed-meshheading:8959777-Transplantation, Homologous
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
Rat cytomegalovirus infection and chronic kidney allograft rejection.
|
| pubmed:affiliation |
Transplantation Laboratory, University of Helsinki, Finland.
|
| pubmed:publicationType |
Journal Article
|