Linked Life Data

8958779

Source:http://linkedlifedata.com/resource/pubmed/id/8958779

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1997-1-2
pubmed:abstractText
To study possible age-related differences in the role of neuronal histaminergic pathways in the control of GH secretion, the effects of alpha-fluoromethylhistidine (alpha-FMH), an irreversible inhibitor of histamine (HA) synthesis, were examined on basal and opioid-induced GH release in neonatal and adult rats. The mechanisms involved in such effects were evaluated by measuring pituitary GH mRNA levels and hypothalamic levels of GH-releasing hormone (GHRH) and somatostatin (SRIF) mRNAs. Daily injection of alpha-FMH (20 mg/kg, s.c.) in pups of either sex, from birth until 10 days of age, caused a significant increase in baseline plasma GH and potentiated the GH response to the [Met5]-enkephalin analog FK 33-824 (1 mg/kg, s.c.) administered 3 h after the last alpha-FMH injection. GH and SRIF mRNA levels were significantly higher in alpha-FMH-treated pups than in controls, whereas no difference was observed in GHRH mRNA levels. In young adult male rats, acute administration of alpha-FMH (100 mg/kg, s.c., 3 h before) did not change significantly basal GH levels but potentiated FK 33-824 (0.3 mg/kg, intracarotid)-induced stimulation of GH secretion. Repeated administration of alpha-FMH (200 micrograms/rat, i.c.v., for 3 days) failed to modify basal and FK 33-824-induced GH secretion, caused a significant reduction in hypothalamic GHRH mRNA levels and left SRIF and GH mRNAs unchanged. These findings indicate that HA exerts an inhibitory effect on GH secretion in both neonatal and adult rats. The different effects of short-term HA depletion on hypothalamic and pituitary indices of somatotropic function observed at the two age periods may be ascribed to the immaturity of the HA system in early postnatal life and to a different functional role of GH-regulatory factors during ontogeny.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0022-0795
pubmed:author
pubmed:issnType
Print
pubmed:volume
151
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
195-201
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:8958779-Aging, pubmed-meshheading:8958779-Analysis of Variance, pubmed-meshheading:8958779-Animals, pubmed-meshheading:8958779-Animals, Newborn, pubmed-meshheading:8958779-D-Ala(2),MePhe(4),Met(0)-ol-enkephalin, pubmed-meshheading:8958779-Female, pubmed-meshheading:8958779-Growth Hormone, pubmed-meshheading:8958779-Growth Hormone-Releasing Hormone, pubmed-meshheading:8958779-Histamine Antagonists, pubmed-meshheading:8958779-Histidine Decarboxylase, pubmed-meshheading:8958779-Hypothalamus, pubmed-meshheading:8958779-Male, pubmed-meshheading:8958779-Methylhistidines, pubmed-meshheading:8958779-Pituitary Gland, pubmed-meshheading:8958779-RNA, Messenger, pubmed-meshheading:8958779-Rats, pubmed-meshheading:8958779-Rats, Sprague-Dawley, pubmed-meshheading:8958779-Somatostatin, pubmed-meshheading:8958779-Weight Gain
pubmed:year
1996
pubmed:articleTitle
Role of the neuronal histaminergic system in the regulation of somatotropic function: comparison between the neonatal and the adult rat.
pubmed:affiliation
Department of Pharmacology, School of Medicine, University of Milan, Italy.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't