| pubmed-article:8958252 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8958252 | lifeskim:mentions | umls-concept:C0007806 | lld:lifeskim |
| pubmed-article:8958252 | lifeskim:mentions | umls-concept:C0011906 | lld:lifeskim |
| pubmed-article:8958252 | lifeskim:mentions | umls-concept:C1511790 | lld:lifeskim |
| pubmed-article:8958252 | lifeskim:mentions | umls-concept:C0032520 | lld:lifeskim |
| pubmed-article:8958252 | lifeskim:mentions | umls-concept:C0599708 | lld:lifeskim |
| pubmed-article:8958252 | lifeskim:mentions | umls-concept:C0487667 | lld:lifeskim |
| pubmed-article:8958252 | lifeskim:mentions | umls-concept:C0205234 | lld:lifeskim |
| pubmed-article:8958252 | lifeskim:mentions | umls-concept:C0598411 | lld:lifeskim |
| pubmed-article:8958252 | lifeskim:mentions | umls-concept:C0598413 | lld:lifeskim |
| pubmed-article:8958252 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:8958252 | pubmed:dateCreated | 1997-1-7 | lld:pubmed |
| pubmed-article:8958252 | pubmed:abstractText | To evaluate whether the detection of Toxoplasma gondii DNA in CSF could contribute to the differential diagnosis of AIDS-related focal brain lesions, CSF samples from 88 HIV-infected patients (56 with focal brain lesions and 32 without) were tested prospectively by a nested PCR for the B1 gene of T. gondii. The assay had a detection limit of 10 trophozoite equivalents. Six of 18 patients with toxoplasmic encephalitis, but none of the 70 patients with other disorders, were PCR-positive (33.3% sensitivity and 100% specificity). Considering only those patients with cerebral toxoplasmosis from whom CSF was collected before or during the first week of antitoxoplasmic therapy, sensitivity rose to 50%. This was higher than the sensitivity in patients whose CSF was collected after the first week of treatment (odds ratio (OR) of 7.0; 95% CI: 0.46-218.2). The administration of antitoxoplasmic prophylaxis did not affect the PCR results. Patients with a poor response to therapy had a higher probability of detectable T. gondii DNA in their CSF (OR of 5.0; 95% CI: 0.37-86.6). All patients with other central nervous system disorders were PCR-negative. Despite the moderate sensitivity, the high specificity and positive predictive value (100%) make this assay a useful tool in the differential diagnosis of AIDS-related focal brain lesions as part of a series of CSF and neuroradiological examinations. | lld:pubmed |
| pubmed-article:8958252 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8958252 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8958252 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8958252 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8958252 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8958252 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8958252 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:8958252 | pubmed:issn | 0022-2615 | lld:pubmed |
| pubmed-article:8958252 | pubmed:author | pubmed-author:GrilliHH | lld:pubmed |
| pubmed-article:8958252 | pubmed:author | pubmed-author:De LucaAA | lld:pubmed |
| pubmed-article:8958252 | pubmed:author | pubmed-author:AntinoriAA | lld:pubmed |
| pubmed-article:8958252 | pubmed:author | pubmed-author:MurryBB | lld:pubmed |
| pubmed-article:8958252 | pubmed:author | pubmed-author:AmmassariAA | lld:pubmed |
| pubmed-article:8958252 | pubmed:author | pubmed-author:CingolaniAA | lld:pubmed |
| pubmed-article:8958252 | pubmed:author | pubmed-author:LinzaloneAA | lld:pubmed |
| pubmed-article:8958252 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8958252 | pubmed:volume | 45 | lld:pubmed |
| pubmed-article:8958252 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8958252 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8958252 | pubmed:pagination | 472-6 | lld:pubmed |
| pubmed-article:8958252 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:8958252 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8958252 | pubmed:articleTitle | PCR detection of Toxoplasma gondii DNA in CSF for the differential diagnosis of AIDS-related focal brain lesions. | lld:pubmed |
| pubmed-article:8958252 | pubmed:affiliation | Department of Infectious Diseases, Catholic University, Rome, Italy. | lld:pubmed |
| pubmed-article:8958252 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8958252 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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