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rdf:type |
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lifeskim:mentions |
umls-concept:C0002085,
umls-concept:C0003069,
umls-concept:C0017349,
umls-concept:C0017785,
umls-concept:C0026809,
umls-concept:C0086418,
umls-concept:C0205396,
umls-concept:C0282580,
umls-concept:C0332307,
umls-concept:C1522240,
umls-concept:C1837204
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pubmed:issue |
11
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pubmed:dateCreated |
1997-1-23
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pubmed:abstractText |
The identification of class II binding peptide epitopes from autoimmune disease-related antigens is an essential step in the development of antigen-specific immune modulation therapy. In the case of type 1 diabetes, T cell and B cell reactivity to the autoantigen glutamic acid decarboxylase 65 (GAD65) is associated with disease development in humans and in nonobese diabetic (NOD) mice. In this study, we identify two DRB1*0401-restricted T cell epitopes from human GAD65, 274-286, and 115-127. Both peptides are immunogenic in transgenic mice expressing functional DRB1*0401 MHC class II molecules but not in nontransgenic littermates. Processing of GAD65 by antigen presenting cells (APC) resulted in the formation of DRB1*0401 complexes loaded with either the 274-286 or 115-127 epitopes, suggesting that these naturally derived epitopes may be displayed on APC recruited into pancreatic islets. The presentation of these two T cell epitopes in the islets of DRB1*0401 individuals who are at risk for type 1 diabetes may allow for antigen-specific recruitment of regulatory cells to the islets following peptide immunization.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8958223-1924293,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8958223-2052549,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8958223-2827008,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8958223-3371661,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8958223-3385490,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8958223-7525393,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8958223-7533299,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8958223-7600288,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8958223-7615790,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8958223-7694152,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8958223-7722439,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8958223-7751636,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8958223-7889403,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8958223-7962558,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8958223-7969282,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8958223-8006581,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8958223-8098789,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8958223-8144889,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8958223-8218409,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8958223-8232539
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0021-9738
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pubmed:author |
pubmed-author:BansalAA,
pubmed-author:ChenS LSL,
pubmed-author:CummingsRR,
pubmed-author:ElliottJ FJF,
pubmed-author:FreedD CDC,
pubmed-author:HermanAA,
pubmed-author:LernmarkAA,
pubmed-author:NepomG TGT,
pubmed-author:PetersonL BLB,
pubmed-author:RothbardJ BJB,
pubmed-author:WhiteleyP JPJ,
pubmed-author:WickerL SLS,
pubmed-author:ZallerD MDM,
pubmed-author:ZhengSS
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
98
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2597-603
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:8958223-Alleles,
pubmed-meshheading:8958223-Amino Acid Sequence,
pubmed-meshheading:8958223-Animals,
pubmed-meshheading:8958223-Autoantibodies,
pubmed-meshheading:8958223-B-Lymphocytes,
pubmed-meshheading:8958223-Cell Line,
pubmed-meshheading:8958223-Diabetes Mellitus, Type 1,
pubmed-meshheading:8958223-Epitopes,
pubmed-meshheading:8958223-Genes, MHC Class II,
pubmed-meshheading:8958223-Glutamate Decarboxylase,
pubmed-meshheading:8958223-HLA-DR Antigens,
pubmed-meshheading:8958223-HLA-DRB1 Chains,
pubmed-meshheading:8958223-Humans,
pubmed-meshheading:8958223-Lymphocyte Activation,
pubmed-meshheading:8958223-Mice,
pubmed-meshheading:8958223-Mice, Inbred NOD,
pubmed-meshheading:8958223-Mice, Transgenic,
pubmed-meshheading:8958223-Molecular Sequence Data,
pubmed-meshheading:8958223-Peptide Fragments,
pubmed-meshheading:8958223-Recombinant Proteins,
pubmed-meshheading:8958223-T-Lymphocytes
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pubmed:year |
1996
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pubmed:articleTitle |
Naturally processed T cell epitopes from human glutamic acid decarboxylase identified using mice transgenic for the type 1 diabetes-associated human MHC class II allele, DRB1*0401.
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pubmed:affiliation |
Department of Autoimmune Diseases Research, Merck Research Laboratories, Rahway, New Jersey 07065-0900, USA. linda_wicker@merck.com
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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