rdf:type |
|
lifeskim:mentions |
umls-concept:C0027061,
umls-concept:C0086022,
umls-concept:C0442335,
umls-concept:C0443252,
umls-concept:C0574032,
umls-concept:C1135183,
umls-concept:C1517499,
umls-concept:C1522318,
umls-concept:C1547239,
umls-concept:C1564874,
umls-concept:C1705099
|
pubmed:issue |
6
|
pubmed:dateCreated |
1997-1-9
|
pubmed:abstractText |
Viral vector-mediated gene transfer into the heart represents a potentially powerful tool for studying both cardiac physiology as well as gene therapy of cardiac disease. We report here the use of a defective viral vector, which expresses no viral gene products, for gene transfer into the mammalian heart. Previous studies have used recombinant viral vectors, which retained viral genes and yielded mostly short-term expression, often with significant inflammation.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
AIM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Dec
|
pubmed:issn |
0003-4975
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
62
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1669-76
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:8957370-Animals,
pubmed-meshheading:8957370-Coronary Vessels,
pubmed-meshheading:8957370-Dependovirus,
pubmed-meshheading:8957370-Gene Transfer Techniques,
pubmed-meshheading:8957370-Genetic Vectors,
pubmed-meshheading:8957370-Heart,
pubmed-meshheading:8957370-Immunohistochemistry,
pubmed-meshheading:8957370-Infusions, Intra-Arterial,
pubmed-meshheading:8957370-Injections,
pubmed-meshheading:8957370-Male,
pubmed-meshheading:8957370-Myocardium,
pubmed-meshheading:8957370-Plasmids,
pubmed-meshheading:8957370-Rats,
pubmed-meshheading:8957370-Rats, Sprague-Dawley,
pubmed-meshheading:8957370-Swine,
pubmed-meshheading:8957370-beta-Galactosidase
|
pubmed:year |
1996
|
pubmed:articleTitle |
Long-term gene transfer in porcine myocardium after coronary infusion of an adeno-associated virus vector.
|
pubmed:affiliation |
Department of Surgery, New York Hospital-Cornell University Medical College, New York, USA.
|
pubmed:publicationType |
Journal Article,
In Vitro
|