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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1997-4-3
|
| pubmed:abstractText |
In the isolated rabbit thoracic aorta and guinea-pig trachea, alpha-mangostin inhibited histamine-induced contractions in a concentration-dependent manner in the presence or absence of cimetidine, a histamine H2 receptor antagonist. But KCl-, phenylephrine- or carbachol-induced contractions were not affected by alpha-mangostin. The concentration-contractile response curve for histamine was shifted to the right in a parallel manner by alpha-mangostin. In the presence of chlorpheniramine, a histamine H1 receptor antagonist, alpha-mangostin did not affect the relaxation of the rabbit aorta induced by histamine. In the guinea-pig trachea, alpha-mangostin had no effect on the relaxation induced by dimaprit, a histamine H2 receptor agonist. alpha-Mangostin caused a concentration-dependent inhibition of the binding of [3H]mepyramine, a specific histamine H1 receptor antagonist to rat aortic smooth muscle cells. Kinetic analysis of [3H]mepyramine binding indicated the competitive inhibition by alpha-mangostin. These results suggest that alpha-mangostin is a novel competitive histamine H1 receptor antagonist in smooth muscle cells.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Histamine H1 Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrilamine,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Histamine H2,
http://linkedlifedata.com/resource/pubmed/chemical/Xanthenes,
http://linkedlifedata.com/resource/pubmed/chemical/Xanthones,
http://linkedlifedata.com/resource/pubmed/chemical/mangostin
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0014-2999
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
31
|
| pubmed:volume |
314
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
351-6
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:8957258-Animals,
pubmed-meshheading:8957258-Aorta, Thoracic,
pubmed-meshheading:8957258-Biomechanics,
pubmed-meshheading:8957258-Cells, Cultured,
pubmed-meshheading:8957258-Guinea Pigs,
pubmed-meshheading:8957258-Histamine H1 Antagonists,
pubmed-meshheading:8957258-Logistic Models,
pubmed-meshheading:8957258-Male,
pubmed-meshheading:8957258-Muscle, Smooth,
pubmed-meshheading:8957258-Muscle, Smooth, Vascular,
pubmed-meshheading:8957258-Pyrilamine,
pubmed-meshheading:8957258-Rabbits,
pubmed-meshheading:8957258-Radioligand Assay,
pubmed-meshheading:8957258-Rats,
pubmed-meshheading:8957258-Rats, Wistar,
pubmed-meshheading:8957258-Receptors, Histamine H2,
pubmed-meshheading:8957258-Vasoconstriction,
pubmed-meshheading:8957258-Vasodilation,
pubmed-meshheading:8957258-Xanthenes,
pubmed-meshheading:8957258-Xanthones
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
Pharmacological properties of alpha-mangostin, a novel histamine H1 receptor antagonist.
|
| pubmed:affiliation |
Department of Pharmaceutical Molecular Biology, Faculty of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
|
| pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
|