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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1997-1-23
|
| pubmed:abstractText |
We examined the influence of apolipoprotein E (apoE) genotype on risk of dementia in 82 adults with Down's syndrome (DS). Compared with those with an apoE 3/3 genotype, the group of adults with DS with apoE 2/4, 3/4, and 4/4 genotypes were 5 times more likely to become demented (RR = 4.7; 95% CI = 1.2, 17.9). We hypothesize that the increased risk of dementia may be mediated by exacerbation of beta-amyloid deposition.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0364-5134
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
40
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
799-801
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:8957023-Adult,
pubmed-meshheading:8957023-Aged,
pubmed-meshheading:8957023-Apolipoprotein E4,
pubmed-meshheading:8957023-Apolipoproteins E,
pubmed-meshheading:8957023-Dementia,
pubmed-meshheading:8957023-Down Syndrome,
pubmed-meshheading:8957023-Female,
pubmed-meshheading:8957023-Genotype,
pubmed-meshheading:8957023-Humans,
pubmed-meshheading:8957023-Incidence,
pubmed-meshheading:8957023-Male,
pubmed-meshheading:8957023-Middle Aged,
pubmed-meshheading:8957023-Risk Assessment,
pubmed-meshheading:8957023-Risk Factors
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
Onset of dementia is associated with apolipoprotein E epsilon4 in Down's syndrome.
|
| pubmed:affiliation |
Laboratory of Epidemiology, NYS Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|