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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
1997-1-2
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pubmed:abstractText |
One hundred and sixty-three breast carcinomas occurring in women aged between 26 and 44 years were examined for pathological features, oestrogen and progesterone receptor status, proliferation as determined by Ki-67 labelling and the presence of c-erbB-2 and p53 protein, and were compared with a control group of carcinomas from women in the 50-67 years age group. Carcinomas occurring in women aged under 35 years had a significantly high incidence of being poorly differentiated and of having high proliferation rates. This group also had a significantly high incidence of p53 protein staining. Carcinomas in the under 30 years age group had a lower incidence of oestrogen and progesterone receptor positivity. No differences were found in c-erbB-2-positive staining between the groups. Infiltrating lobular carcinomas were only identified in women aged 40 years and over. There was a higher incidence of a family history in the 35-44 years age group (18%) than in the under 35 years age group (11%). Breast carcinomas occurring in women aged under 35 years are more aggressive. An important finding is the high incidence of p53 positivity, which may indicate genetic instability.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8956795-1317462,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8956795-1323840,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8956795-1351156,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8956795-1355464,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8956795-1484317,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8956795-1517889,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8956795-1525830,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8956795-1617667,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8956795-1672253,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8956795-1757079,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8956795-1832908,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8956795-2208173,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8956795-2571356,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8956795-2676151,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8956795-3355766,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8956795-3697919,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8956795-3736639,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8956795-6174202,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8956795-7214841,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8956795-7281483,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8956795-7514027,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8956795-7530599,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8956795-7622286,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8956795-7684021,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/8956795-8156519,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8956795-8394732,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8956795-8630946,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8956795-890672
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0007-0920
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
74
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1796-800
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8956795-Adult,
pubmed-meshheading:8956795-Age Distribution,
pubmed-meshheading:8956795-Age Factors,
pubmed-meshheading:8956795-Breast Neoplasms,
pubmed-meshheading:8956795-Carcinoma, Ductal, Breast,
pubmed-meshheading:8956795-Family Health,
pubmed-meshheading:8956795-Female,
pubmed-meshheading:8956795-Humans,
pubmed-meshheading:8956795-Tumor Markers, Biological
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pubmed:year |
1996
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pubmed:articleTitle |
Breast carcinomas occurring in young women (< 35 years) are different.
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pubmed:affiliation |
Breast Cancer Research Unit, University of Leicester, Glenfield Hospital, UK.
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pubmed:publicationType |
Journal Article
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