Linked Life Data

8956371

Source:http://linkedlifedata.com/resource/pubmed/id/8956371

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1997-3-12
pubmed:abstractText
Estrogens have been reported to influence endothelial functions. This article's aim is to examine whether endothelium-dependent vasodilation of brachial arteries is changed in parallel with the physiological variation of the ovarian hormones during the menstrual cycle in young healthy female subjects. With high-resolution ultrasonography, we measured the diameter and blood flow of brachial arteries at rest, during reactive hyperemia, and after sublingual nitroglycerin administration in 15 young healthy female subjects (mean 29.6 +/- 2.6 years). All female subjects were studied in each of three different phases of one menstrual cycle (M, menstrual phase; F, follicular phase; L, luteal phase). The increase in arterial diameter during reactive hyperemia was lowest in the menstrual phase and highest in the follicular phase (4.9 +/- 0.8% in M; 14.1 +/- 0.9% in F; 9.2 +/- 1.1% in L; p < 0.005 between any two means among the groups). No significant difference was apparent in the percentage of increase in blood flow during reactive hyperemia among the three phases. The percentage of increase in arterial diameter after nitroglycerin administration also was not significantly different among the three phases of the cycle. The serum estradiol level was lowest in the menstrual phase and was highest in the follicular phase (17.5 +/- 1.6 pg/ml in M, p < 0.0005, M versus F and L; 107.8 +/- 18.0 pg/ml in F, p < 0.05, F versus L; 74.4 +/- 7.3 pg/ml in L). The serum level of nitrite-nitrate, measured by the Griess reaction, was highest in the follicular phase and was lowest in the menstrual phase of the three different phases (40.4 +/- 7.9 mumol/l in M, p < 0.01, M versus F, and p < 0.05, M versus L; 106.7 +/- 17.6 mumol/l in F, p < 0.05, F versus L; 62.2 +/- 6.2 mumol/l in L). In conclusion, a significant variation of the endothelium-dependent vasodilation parallels the levels of serum estradiol and nitrite-nitrate during the menstrual cycle in female subjects.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1081-650X
pubmed:author
pubmed:issnType
Print
pubmed:volume
108
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
473-80
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Menstrual cyclic variation of endothelium-dependent vasodilation of the brachial artery: possible role of estrogen and nitric oxide.
pubmed:affiliation
Division of Cardiology, Kumamoto University School of Medicine, Japan.
pubmed:publicationType
Journal Article, Clinical Trial, Randomized Controlled Trial