Linked Life Data

8956154

Source:http://linkedlifedata.com/resource/pubmed/id/8956154

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1997-3-5
pubmed:abstractText
Polymorphisms in the genes for the low-density lipoprotein (LDL) receptor ligands, apolipoprotein E (apoE), and apolipoprotein B (apoB) are associated with variation in plasma levels of LDL cholesterol. Lp(a) lipoprotein(a) [Lp(a)] is LDL in which apoB is attached to a glycoprotein called apolipoprotein(a) [apo(a)]. Apo(a) has several genetically determined isoforms differing in molecular weight, which are inversely correlated with Lp(a) concentrations in blood. The interaction of apo(a) with triglyceride-rich lipoproteins differs with the size of apo(a), and therefore the effects of apoE gene polymorphism on Lp(a) levels could also depend on apo(a) size. We have investigated the possible effect of genetic variation in the apoE and apoB genes on plasma Lp(a) concentrations in 466 white men with different apo(a) phenotypes. Overall there was no significant association between the common apoE polymorphism and Lp(a), but in the subgroup with apo(a)-S4, concentrations of Lp(a) differed significantly among the apoE genotypes (P = 0.05). Lp(a) was highest in the apoE genotypes epsilon 2 epsilon 3 and epsilon 3 epsilon 3 and lowest in genotype epsilon 3 epsilon 4, and the apoE polymorphism was estimated to account for about 2.4% of the variation in Lp(a). In contrast, in the subgroup with apo(a)-S2 Lp(a) was significantly lower (P = 0.04) in apoE genotype epsilon 2 epsilon 3 than in genotype epsilon 3 epsilon 3. Lp(a) concentrations did not differ among the XbaI (P = 0.65) or SP 24/27 (P = 0.26) polymorphisms of the apoB gene. The expected effects of both apoE and apoB polymorphism on LDL levels were significant in the whole population sample and in subjects with large-sized apo(a) isoforms (P < 0.01), whereas no effect was seen in those with low molecular weight apo(a) isoforms. We conclude that the influence of apoE genotypes on Lp(a) concentrations depends on the size of the apo(a) molecule in Lp(a), possibly because both apo(a)-S4 and apoE4 have high affinity for triglyceride-rich lipoproteins and may be taken up and degraded rapidly by remnant receptors.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0946-2716
pubmed:author
pubmed:issnType
Print
pubmed:volume
74
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
685-90
pubmed:dateRevised
2011-7-8
pubmed:meshHeading
pubmed-meshheading:8956154-Apolipoproteins A, pubmed-meshheading:8956154-Apolipoproteins E, pubmed-meshheading:8956154-Body Weight, pubmed-meshheading:8956154-Cholesterol, pubmed-meshheading:8956154-Coronary Disease, pubmed-meshheading:8956154-European Continental Ancestry Group, pubmed-meshheading:8956154-Humans, pubmed-meshheading:8956154-Lipoprotein(a), pubmed-meshheading:8956154-Lipoproteins, LDL, pubmed-meshheading:8956154-Male, pubmed-meshheading:8956154-Molecular Weight, pubmed-meshheading:8956154-Phenotype, pubmed-meshheading:8956154-Plasminogen Activators, pubmed-meshheading:8956154-Polymorphism, Genetic, pubmed-meshheading:8956154-Polymorphism, Restriction Fragment Length, pubmed-meshheading:8956154-Regression Analysis, pubmed-meshheading:8956154-Risk Factors, pubmed-meshheading:8956154-Triglycerides
pubmed:year
1996
pubmed:articleTitle
Effects of apoE gene polymorphism on Lp(a) concentrations depend on the size of apo(a): a study of 466 white men.
pubmed:affiliation
Department of Internal Medicine and Cardiology A, University of Aarhus, Denmark.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't