| pubmed-article:8954137 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8954137 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:8954137 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:8954137 | lifeskim:mentions | umls-concept:C0024432 | lld:lifeskim |
| pubmed-article:8954137 | lifeskim:mentions | umls-concept:C0042874 | lld:lifeskim |
| pubmed-article:8954137 | lifeskim:mentions | umls-concept:C0387583 | lld:lifeskim |
| pubmed-article:8954137 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:8954137 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:8954137 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:8954137 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:8954137 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:8954137 | pubmed:dateCreated | 1997-1-7 | lld:pubmed |
| pubmed-article:8954137 | pubmed:abstractText | To clarify the role of vitamin E (alpha-tocopherol) for the induction of cyclooxygenase-2 (COX-2) in rat macrophages stimulated by lipopolysaccharide (LPS), vitamin E-enriched macrophages were prepared by intraperitoneal injection of vitamin E for 6 days at a rate of 5 mg per day. The production of PGE2 was increased in dose- and time-dependent manners by addition of LPS in both control and vitamin E-enriched peritoneal macrophages. The maximum effect of LPS was observed in 12 h at concentration of 5 micrograms/ml. By analyzing COX-2 mRNA level by Northern blot and COX-2 enzyme mass and phosphotyrosine by Western blot, it was revealed that the increase of PGE2 production reflected the induction of COX-2 expression through activation of tyrosine kinase. Vitamin E failed to inhibit PGE2 production in LPS-stimulated macrophages; however, genistein, a tyrosine kinase inhibitor, completely inhibited the production at 100 microM. These results suggest that vitamin E does not inhibit COX-2 expression via LPS-mediated tyrosine kinase signal transduction pathway. | lld:pubmed |
| pubmed-article:8954137 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8954137 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8954137 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8954137 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8954137 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8954137 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8954137 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8954137 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8954137 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8954137 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8954137 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8954137 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8954137 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8954137 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8954137 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8954137 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:8954137 | pubmed:issn | 0006-3002 | lld:pubmed |
| pubmed-article:8954137 | pubmed:author | pubmed-author:UedaNN | lld:pubmed |
| pubmed-article:8954137 | pubmed:author | pubmed-author:YamamotoSS | lld:pubmed |
| pubmed-article:8954137 | pubmed:author | pubmed-author:FujieKK | lld:pubmed |
| pubmed-article:8954137 | pubmed:author | pubmed-author:SakamotoWW | lld:pubmed |
| pubmed-article:8954137 | pubmed:author | pubmed-author:HandaHH | lld:pubmed |
| pubmed-article:8954137 | pubmed:author | pubmed-author:NishihiraJJ | lld:pubmed |
| pubmed-article:8954137 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8954137 | pubmed:day | 22 | lld:pubmed |
| pubmed-article:8954137 | pubmed:volume | 1304 | lld:pubmed |
| pubmed-article:8954137 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8954137 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8954137 | pubmed:pagination | 139-44 | lld:pubmed |
| pubmed-article:8954137 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:8954137 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8954137 | pubmed:articleTitle | Effect of vitamin E on expression of cyclooxygenase-2 in lipopolysaccharide-stimulated rat macrophages. | lld:pubmed |
| pubmed-article:8954137 | pubmed:affiliation | Department of Biochemistry, School of Dentistry, Sapporo, Japan. | lld:pubmed |
| pubmed-article:8954137 | pubmed:publicationType | Journal Article | lld:pubmed |
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