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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1977-10-28
|
| pubmed:abstractText |
Microbial transformation experiments have been conducted with the antitumor alkaloid, d-tetrandrine. The alkaloid is selectively demethylated at the N-(2)-position by Cunninghamella blakesleeana ATCC 8688a. The biotransformation reaction is highly selective and uncomplicated by side-product formation. N-demethylation of the alkaloid using methylchloroformate is not regio-specific. Procedures used in screening microorganisms for their abilities to yield metabolites of d-tetrandrine are evaluated.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0024-5461
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
40
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
239-46
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:895382-Alkaloids,
pubmed-meshheading:895382-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:895382-Fungi,
pubmed-meshheading:895382-Isoquinolines,
pubmed-meshheading:895382-Magnetic Resonance Spectroscopy,
pubmed-meshheading:895382-Molecular Conformation,
pubmed-meshheading:895382-Mucorales,
pubmed-meshheading:895382-Species Specificity,
pubmed-meshheading:895382-Structure-Activity Relationship
|
| pubmed:articleTitle |
Microbial transformations of natural antitumor agents. IV. Formation of N-(2)-nor-d-tetrandrine by Cunninghamella blakesleeana (ATCC 8688a).
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|