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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5295
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pubmed:dateCreated |
1997-1-9
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pubmed:abstractText |
The human Kv1.5 potassium channel (hKv1.5) contains proline-rich sequences identical to those that bind to Src homology 3 (SH3) domains. Direct association of the Src tyrosine kinase with cloned hKv1.5 and native hKv1.5 in human myocardium was observed. This interaction was mediated by the proline-rich motif of hKv1.5 and the SH3 domain of Src. Furthermore, hKv1.5 was tyrosine phosphorylated, and the channel current was suppressed, in cells coexpressing v-Src. These results provide direct biochemical evidence for a signaling complex composed of a potassium channel and a protein tyrosine kinase.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
20
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pubmed:volume |
274
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2089-91
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:8953041-Amino Acid Sequence,
pubmed-meshheading:8953041-Cell Line,
pubmed-meshheading:8953041-Cloning, Molecular,
pubmed-meshheading:8953041-Humans,
pubmed-meshheading:8953041-Kv1.5 Potassium Channel,
pubmed-meshheading:8953041-Molecular Sequence Data,
pubmed-meshheading:8953041-Myocardium,
pubmed-meshheading:8953041-Oncogene Protein pp60(v-src),
pubmed-meshheading:8953041-Patch-Clamp Techniques,
pubmed-meshheading:8953041-Phosphorylation,
pubmed-meshheading:8953041-Phosphotyrosine,
pubmed-meshheading:8953041-Potassium Channels,
pubmed-meshheading:8953041-Potassium Channels, Voltage-Gated,
pubmed-meshheading:8953041-Recombinant Fusion Proteins,
pubmed-meshheading:8953041-Signal Transduction,
pubmed-meshheading:8953041-Transfection,
pubmed-meshheading:8953041-src Homology Domains,
pubmed-meshheading:8953041-src-Family Kinases
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pubmed:year |
1996
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pubmed:articleTitle |
Association of Src tyrosine kinase with a human potassium channel mediated by SH3 domain.
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pubmed:affiliation |
Department of Biochemistry and Volen Center for Complex Systems, Brandeis University, Waltham, MA 02254, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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