| pubmed-article:8952524 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8952524 | lifeskim:mentions | umls-concept:C0036220 | lld:lifeskim |
| pubmed-article:8952524 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:8952524 | lifeskim:mentions | umls-concept:C0086661 | lld:lifeskim |
| pubmed-article:8952524 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:8952524 | lifeskim:mentions | umls-concept:C0032200 | lld:lifeskim |
| pubmed-article:8952524 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:8952524 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:8952524 | lifeskim:mentions | umls-concept:C0600210 | lld:lifeskim |
| pubmed-article:8952524 | lifeskim:mentions | umls-concept:C1514485 | lld:lifeskim |
| pubmed-article:8952524 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:8952524 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:8952524 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:8952524 | pubmed:dateCreated | 1997-1-14 | lld:pubmed |
| pubmed-article:8952524 | pubmed:abstractText | Platelet-derived growth factor-B (PDGF-B) is a potent paracrine-acting mitogen in Kaposi's sarcoma (KS) lesions. Interferon-alpha is widely used for clinical treatment of KS. Here we show that platelet-derived growth factor-B activates proliferation and migration of cultivated AIDS-KS spindle cells whereas interferon-alpha acts as an inhibitor. At the molecular level, these opposite activities of platelet-derived growth factor-B and interferon-alpha converged onto the adverse regulation of the c-myc gene expression. Platelet-derived growth factor-B induced c-myc mRNA and protein synthesis in cultivated AIDS-KS spindle cells whereas interferon-alpha inhibited these processes. Using c-myc-specific phoshothioate antisense oligodeoxynucleotides, we demonstrated that down-regulation of c-myc expression is sufficient to inhibit proliferation and migration of KS spindle cells in vitro. This indicated that c-Myc protein may be an important regulatory molecule of KS spindle cell proliferation and migration. High amounts of the c-Myc protein were detected in the nuclei of KS spindle cells in histological sections of AIDS-KS biopsies. This suggested that the c-myc gene may also regulate proliferation and migration of AIDS-KS spindle cells in vivo. In this case, c-myc may play an important role in the focus of major pathogenic and therapeutic pathways of KS. | lld:pubmed |
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| pubmed-article:8952524 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8952524 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8952524 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:8952524 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8952524 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:8952524 | pubmed:issn | 0002-9440 | lld:pubmed |
| pubmed-article:8952524 | pubmed:author | pubmed-author:KösterRR | lld:pubmed |
| pubmed-article:8952524 | pubmed:author | pubmed-author:ZietzCC | lld:pubmed |
| pubmed-article:8952524 | pubmed:author | pubmed-author:StürzlMM | lld:pubmed |
| pubmed-article:8952524 | pubmed:author | pubmed-author:BlattL MLM | lld:pubmed |
| pubmed-article:8952524 | pubmed:author | pubmed-author:BryschWW | lld:pubmed |
| pubmed-article:8952524 | pubmed:author | pubmed-author:HermekingHH | lld:pubmed |
| pubmed-article:8952524 | pubmed:author | pubmed-author:StreubertMM | lld:pubmed |
| pubmed-article:8952524 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8952524 | pubmed:volume | 149 | lld:pubmed |
| pubmed-article:8952524 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8952524 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8952524 | pubmed:pagination | 1871-85 | lld:pubmed |
| pubmed-article:8952524 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:8952524 | pubmed:meshHeading | pubmed-meshheading:8952524-... | lld:pubmed |
| pubmed-article:8952524 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8952524 | pubmed:articleTitle | Consensus-interferon and platelet-derived growth factor adversely regulate proliferation and migration of Kaposi's sarcoma cells by control of c-myc expression. | lld:pubmed |
| pubmed-article:8952524 | pubmed:affiliation | Abteilung Virusforschung, Max-Planck-Institut für Biochemie, Martinsried, Germany. | lld:pubmed |
| pubmed-article:8952524 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8952524 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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