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rdf:type |
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lifeskim:mentions |
umls-concept:C0007634,
umls-concept:C0017262,
umls-concept:C0032200,
umls-concept:C0036220,
umls-concept:C0086661,
umls-concept:C0185117,
umls-concept:C0600210,
umls-concept:C0851285,
umls-concept:C1514485,
umls-concept:C2587213,
umls-concept:C2911684
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pubmed:issue |
6
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pubmed:dateCreated |
1997-1-14
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pubmed:abstractText |
Platelet-derived growth factor-B (PDGF-B) is a potent paracrine-acting mitogen in Kaposi's sarcoma (KS) lesions. Interferon-alpha is widely used for clinical treatment of KS. Here we show that platelet-derived growth factor-B activates proliferation and migration of cultivated AIDS-KS spindle cells whereas interferon-alpha acts as an inhibitor. At the molecular level, these opposite activities of platelet-derived growth factor-B and interferon-alpha converged onto the adverse regulation of the c-myc gene expression. Platelet-derived growth factor-B induced c-myc mRNA and protein synthesis in cultivated AIDS-KS spindle cells whereas interferon-alpha inhibited these processes. Using c-myc-specific phoshothioate antisense oligodeoxynucleotides, we demonstrated that down-regulation of c-myc expression is sufficient to inhibit proliferation and migration of KS spindle cells in vitro. This indicated that c-Myc protein may be an important regulatory molecule of KS spindle cell proliferation and migration. High amounts of the c-Myc protein were detected in the nuclei of KS spindle cells in histological sections of AIDS-KS biopsies. This suggested that the c-myc gene may also regulate proliferation and migration of AIDS-KS spindle cells in vivo. In this case, c-myc may play an important role in the focus of major pathogenic and therapeutic pathways of KS.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8952524-1323124,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8952524-13872176,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8952524-1388902,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8952524-1457189,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8952524-1497324,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8952524-1560343,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8952524-1573283,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8952524-1690381,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8952524-1933723,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8952524-2022594,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8952524-2153568,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8952524-2415966,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8952524-2439522,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8952524-2541390,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8952524-3141299,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8952524-3235597,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8952524-3277186,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8952524-3280975,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8952524-3302722,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8952524-3860831,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8952524-3881681,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8952524-3901851,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8952524-6088986,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8952524-6431612,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8952524-6606489,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8952524-7287964,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8952524-7519018,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8952524-7528513,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8952524-7732029,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8952524-7753843,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8952524-7761101,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8952524-7923926,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8952524-7935812,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8952524-7969490,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8952524-7997879,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8952524-8113414,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8952524-8415749,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8952524-8421701,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8952524-8952523
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0002-9440
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
149
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1871-85
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8952524-Cell Division,
pubmed-meshheading:8952524-Cell Movement,
pubmed-meshheading:8952524-Consensus Sequence,
pubmed-meshheading:8952524-Fibroblast Growth Factor 2,
pubmed-meshheading:8952524-Gene Expression Regulation,
pubmed-meshheading:8952524-Genes, myc,
pubmed-meshheading:8952524-Humans,
pubmed-meshheading:8952524-Interferon-alpha,
pubmed-meshheading:8952524-Male,
pubmed-meshheading:8952524-Platelet-Derived Growth Factor,
pubmed-meshheading:8952524-Proto-Oncogene Proteins c-myc,
pubmed-meshheading:8952524-Sarcoma, Kaposi,
pubmed-meshheading:8952524-Tumor Cells, Cultured
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pubmed:year |
1996
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pubmed:articleTitle |
Consensus-interferon and platelet-derived growth factor adversely regulate proliferation and migration of Kaposi's sarcoma cells by control of c-myc expression.
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pubmed:affiliation |
Abteilung Virusforschung, Max-Planck-Institut für Biochemie, Martinsried, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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