Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1997-4-14
pubmed:abstractText
The POU domain transcription factor Oct-6 (SCIP/Tst-1) is likely to control important stages of Schwann cell development, including the initiation of myelination around birth. Here, we use immunocytochemical and reverse transcriptase-polymerase chain reaction techniques to examine Oct-6 earlier in nerve development, to test the idea that Oct-6 has an additional role in Schwann cell precursors or early embryonic Schwann cells, a possibility raised by previous studies on transgenic mice. Consistent with this, we find low but unambiguous levels of Oct-6 mRNA and protein in Schwann cell precursors of mouse and rat (nerves from 12- and 14-day-old embryos, respectively), with expression levels gradually increasing during early Schwann cell development and towards birth. Unexpectedly, Oct-6 immunoreactivity is clearly present in nuclei of most myelinating cells at least as late as postnatal day 12. Furthermore, many nonmyelinating Schwann cells express Oct-6 in adult life. A comparison of Oct-6 mRNA with other Schwann cell transcription factors-namely, Oct-1, Krox-20, and Pax-3-reveals that each factor exhibits strong developmental regulation and a unique expression pattern in embryonic nerves. Therefore, they are likely to play distinct regulatory roles in early development of the Schwann cell lineage.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Early Growth Response Protein 2, http://linkedlifedata.com/resource/pubmed/chemical/Egr2 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Egr2 protein, rat, http://linkedlifedata.com/resource/pubmed/chemical/Fetal Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Hcfc1 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Host Cell Factor C1, http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Octamer Transcription Factor-1, http://linkedlifedata.com/resource/pubmed/chemical/Octamer Transcription Factor-6, http://linkedlifedata.com/resource/pubmed/chemical/Paired Box Transcription Factors, http://linkedlifedata.com/resource/pubmed/chemical/Pax3 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Pou2f1 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Pou2f1 protein, rat, http://linkedlifedata.com/resource/pubmed/chemical/Pou3f1 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Pou3f1 protein, rat, http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger, http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0360-4012
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
46
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
630-40
pubmed:dateRevised
2009-9-29
pubmed:meshHeading
pubmed-meshheading:8951674-Animals, pubmed-meshheading:8951674-Cell Lineage, pubmed-meshheading:8951674-DNA-Binding Proteins, pubmed-meshheading:8951674-Early Growth Response Protein 2, pubmed-meshheading:8951674-Fetal Proteins, pubmed-meshheading:8951674-Fluorescent Antibody Technique, Indirect, pubmed-meshheading:8951674-Gene Expression Regulation, Developmental, pubmed-meshheading:8951674-Gestational Age, pubmed-meshheading:8951674-Homeodomain Proteins, pubmed-meshheading:8951674-Host Cell Factor C1, pubmed-meshheading:8951674-In Situ Hybridization, pubmed-meshheading:8951674-Mice, pubmed-meshheading:8951674-Myelin Sheath, pubmed-meshheading:8951674-Nerve Fibers, Myelinated, pubmed-meshheading:8951674-Nerve Tissue Proteins, pubmed-meshheading:8951674-Octamer Transcription Factor-1, pubmed-meshheading:8951674-Octamer Transcription Factor-6, pubmed-meshheading:8951674-Paired Box Transcription Factors, pubmed-meshheading:8951674-Peripheral Nerves, pubmed-meshheading:8951674-Polymerase Chain Reaction, pubmed-meshheading:8951674-RNA, Messenger, pubmed-meshheading:8951674-Rats, pubmed-meshheading:8951674-Rats, Sprague-Dawley, pubmed-meshheading:8951674-Schwann Cells, pubmed-meshheading:8951674-Sciatic Nerve, pubmed-meshheading:8951674-Stem Cells, pubmed-meshheading:8951674-Sympathetic Nervous System, pubmed-meshheading:8951674-Transcription Factors
pubmed:year
1996
pubmed:articleTitle
Oct-6 (SCIP/Tst-1) is expressed in Schwann cell precursors, embryonic Schwann cells, and postnatal myelinating Schwann cells: comparison with Oct-1, Krox-20, and Pax-3.
pubmed:affiliation
Department of Anatomy and Developmental Biology, University College London, England.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't