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rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0004595,
umls-concept:C0017337,
umls-concept:C0036667,
umls-concept:C0039476,
umls-concept:C0041249,
umls-concept:C0041261,
umls-concept:C0049190,
umls-concept:C0204727,
umls-concept:C0205409,
umls-concept:C0312418,
umls-concept:C0683598,
umls-concept:C1880022
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pubmed:issue |
1-2
|
|
pubmed:dateCreated |
1997-1-7
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|
pubmed:databankReference |
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|
pubmed:abstractText |
The mutant trpS gene of Bacillus subtilis encoding a thermosensitive tryptophanyl-tRNA synthetase that also confers resistance to growth inhibition by 5-fluorotryptophan at permissive temperature has been isolated and characterized. A point mutation at codon 82 of the gene from a wild-type TCA codon for Ser to a TTA codon for Leu has been identified.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
0006-3002
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
11
|
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pubmed:volume |
1309
|
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pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
42-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8950174-Bacillus subtilis,
pubmed-meshheading:8950174-Cloning, Molecular,
pubmed-meshheading:8950174-DNA Mutational Analysis,
pubmed-meshheading:8950174-Drug Resistance, Microbial,
pubmed-meshheading:8950174-Genes, Bacterial,
pubmed-meshheading:8950174-Molecular Sequence Data,
pubmed-meshheading:8950174-Point Mutation,
pubmed-meshheading:8950174-Protein Conformation,
pubmed-meshheading:8950174-Temperature,
pubmed-meshheading:8950174-Tryptophan,
pubmed-meshheading:8950174-Tryptophan-tRNA Ligase
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|
pubmed:year |
1996
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|
pubmed:articleTitle |
Isolation and characterization of the Bacillus subtilis tryptophanyl-tRNA synthetase gene (trpS) conferring 5-fluorotryptophan resistance and temperature sensitivity.
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pubmed:affiliation |
Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, Hong Kong.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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