Linked Life Data

8947989

Source:http://linkedlifedata.com/resource/pubmed/id/8947989

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1997-3-21
pubmed:abstractText
This study explored the variability of zidovudine concentrations with computer simulations and measured concentrations. A one-compartment oral absorption model was selected to characterize zidovudine disposition. Mean (+/-standard deviation) values for the pharmacokinetic parameters were taken from the literature. Five different Monte Carlo simulations (50 each) were performed of zidovudine concentrations following repetitive administration of 100-mg oral doses 6 times/day in patients weighing 45-85 kg. A sixth simulation considered a weight-adjusted regimen. Predicted concentrations were compared with those measured in 30 HIV-infected persons receiving 100 mg/dose. Predicted concentrations 1 hour after 100 mg was administered fell in the range of 0.52-5.18 microM; measured values in 30 patients were 0.54-3.07 microM. This study confirms substantial variability in zidovudine serum concentrations. The simulation study of a weight-adjusted regimen suggests one possibility to reduce this variability. These observations provide a basis to explore dosing strategies that control for pharmacokinetic and perhaps pharmacodynamic sources of interpatient variability.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0277-0008
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1154-8
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:articleTitle
Variability in zidovudine serum concentrations.
pubmed:affiliation
Department of Pharmacy Practice, University of Minnesota Academic Health Sciences Center, Minneapolis 55455, USA.
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study, Research Support, U.S. Gov't, P.H.S.