Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1996-12-30
pubmed:abstractText
The induction of antibodies against peptides requires the presence of a T helper cell epitope. In the absence of an added T-cell epitope only 10% of the mice, or less depending on the strain, gave an antibody response to a series of peptides of the measles virus (MV) fusion (F) protein. After coimmunization with a non-covalently coupled T-cell epitope more than 60% of the peptides became immunogenic. Considerable differences became apparent when BALB/c mice were immunized with peptides in the presence of different T-cell epitopes. An immunodominant T-cell epitope of the MV-F protein was more efficient than a subdominant or a cryptic T-cell epitope in providing help to a non-linked B-cell epitope. There is both a ranking order of the amount of help which B-cell epitopes require and a ranking order for the help T-cell epitopes are able to provide. The capability of a T-cell epitope to provide help to a B-cell epitope correlated with its own immunogenicity, i.e. the intensity of the antibody response to the peptide representing the T-cell epitope. The data suggest that for each MHC class II allele there is an optimal T-cell epitope which can provide help to a maximal number of B-cell epitopes and that such a peptide can be identified by its ability to induce antibodies against itself. By using this strategy, the authors were able to induce antibodies which cross-reacted with the MV.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0300-9475
pubmed:author
pubmed:issnType
Print
pubmed:volume
44
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
478-84
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:8947599-Animals, pubmed-meshheading:8947599-Antigens, Viral, pubmed-meshheading:8947599-B-Lymphocytes, pubmed-meshheading:8947599-Cross Reactions, pubmed-meshheading:8947599-Epitopes, pubmed-meshheading:8947599-Haplotypes, pubmed-meshheading:8947599-Histocompatibility Antigens Class II, pubmed-meshheading:8947599-Immunization, pubmed-meshheading:8947599-Immunodominant Epitopes, pubmed-meshheading:8947599-Lymphocyte Cooperation, pubmed-meshheading:8947599-Measles virus, pubmed-meshheading:8947599-Mice, pubmed-meshheading:8947599-Mice, Inbred BALB C, pubmed-meshheading:8947599-Mice, Inbred C57BL, pubmed-meshheading:8947599-Peptide Fragments, pubmed-meshheading:8947599-Specific Pathogen-Free Organisms, pubmed-meshheading:8947599-T-Lymphocytes, Helper-Inducer, pubmed-meshheading:8947599-Viral Fusion Proteins
pubmed:year
1996
pubmed:articleTitle
Hierarchic T-cell help to non-linked B-cell epitopes.
pubmed:affiliation
Laboratorie National de Santé, Luxembourg, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't