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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
1996-12-30
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pubmed:abstractText |
The induction of antibodies against peptides requires the presence of a T helper cell epitope. In the absence of an added T-cell epitope only 10% of the mice, or less depending on the strain, gave an antibody response to a series of peptides of the measles virus (MV) fusion (F) protein. After coimmunization with a non-covalently coupled T-cell epitope more than 60% of the peptides became immunogenic. Considerable differences became apparent when BALB/c mice were immunized with peptides in the presence of different T-cell epitopes. An immunodominant T-cell epitope of the MV-F protein was more efficient than a subdominant or a cryptic T-cell epitope in providing help to a non-linked B-cell epitope. There is both a ranking order of the amount of help which B-cell epitopes require and a ranking order for the help T-cell epitopes are able to provide. The capability of a T-cell epitope to provide help to a B-cell epitope correlated with its own immunogenicity, i.e. the intensity of the antibody response to the peptide representing the T-cell epitope. The data suggest that for each MHC class II allele there is an optimal T-cell epitope which can provide help to a maximal number of B-cell epitopes and that such a peptide can be identified by its ability to induce antibodies against itself. By using this strategy, the authors were able to induce antibodies which cross-reacted with the MV.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Epitopes,
http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens Class II,
http://linkedlifedata.com/resource/pubmed/chemical/Immunodominant Epitopes,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Viral Fusion Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0300-9475
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
44
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
478-84
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8947599-Animals,
pubmed-meshheading:8947599-Antigens, Viral,
pubmed-meshheading:8947599-B-Lymphocytes,
pubmed-meshheading:8947599-Cross Reactions,
pubmed-meshheading:8947599-Epitopes,
pubmed-meshheading:8947599-Haplotypes,
pubmed-meshheading:8947599-Histocompatibility Antigens Class II,
pubmed-meshheading:8947599-Immunization,
pubmed-meshheading:8947599-Immunodominant Epitopes,
pubmed-meshheading:8947599-Lymphocyte Cooperation,
pubmed-meshheading:8947599-Measles virus,
pubmed-meshheading:8947599-Mice,
pubmed-meshheading:8947599-Mice, Inbred BALB C,
pubmed-meshheading:8947599-Mice, Inbred C57BL,
pubmed-meshheading:8947599-Peptide Fragments,
pubmed-meshheading:8947599-Specific Pathogen-Free Organisms,
pubmed-meshheading:8947599-T-Lymphocytes, Helper-Inducer,
pubmed-meshheading:8947599-Viral Fusion Proteins
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pubmed:year |
1996
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pubmed:articleTitle |
Hierarchic T-cell help to non-linked B-cell epitopes.
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pubmed:affiliation |
Laboratorie National de Santé, Luxembourg, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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