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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
22
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pubmed:dateCreated |
1997-1-9
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pubmed:abstractText |
The mechanisms by which apoptosis is prevented by survival factors are largely unknown. Using an interaction cloning approach, we identified a protein that binds to the intracellular domain of the hepatocyte growth factor (HGF) receptor. This protein was identified as BAG-1, a recently characterized Bcl-2 functional partner, which prolongs cell survival through unknown mechanisms. Overexpression of BAG-1 in liver progenitor cells enhances protection from apoptosis by HGF. Association of the receptor with BAG-1 occurs in intact cells, is mediated by the C-terminal region of BAG-1 and is independent from tyrosine phosphorylation of the receptor. Formation of the complex is increased rapidly following induction of apoptosis. BAG-1 also enhances platelet-derived growth factor (PDGF)-mediated protection from apoptosis and associates with the PDGF receptor. Microinjection or transient expression of BAG-1 deletion mutants shows that both the N- and the C-terminal domains are required for protection from apoptosis. The finding of a link between growth factor receptors and the anti-apoptotic machinery fills a gap in the understanding of the molecular events regulating programmed cell death.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8947043-1328986,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8947043-1383237,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8947043-1557121,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8947043-1655790,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8947043-1718989,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8947043-1835669,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8947043-1846706,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8947043-1917129,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8947043-2541345,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8947043-2554238,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8947043-2829204,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8947043-2952888,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8947043-3041007,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8947043-3529086,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8947043-7513258,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8947043-7542991,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8947043-7592796,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8947043-7608139,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8947043-7687741,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8947043-7791872,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8947043-7822285,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8947043-7834747,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8947043-7854452,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8947043-7878463,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8947043-8045259,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8947043-8106557,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8947043-8168488,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8947043-8183564,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8947043-8205613,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8947043-8235590,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8947043-8293575,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8947043-8302603,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8947043-8381212,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8947043-8387483,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8947043-8522613,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8947043-8730094
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Apoptosis Regulatory Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/BCL2-associated athanogene 1 protein,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Etoposide,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-met,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Platelet-Derived Growth...,
http://linkedlifedata.com/resource/pubmed/chemical/Staurosporine,
http://linkedlifedata.com/resource/pubmed/chemical/TP53BP2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Tyrosine
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0261-4189
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6205-12
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:8947043-Animals,
pubmed-meshheading:8947043-Apoptosis,
pubmed-meshheading:8947043-Apoptosis Regulatory Proteins,
pubmed-meshheading:8947043-Blotting, Western,
pubmed-meshheading:8947043-Carrier Proteins,
pubmed-meshheading:8947043-Cells, Cultured,
pubmed-meshheading:8947043-Cloning, Molecular,
pubmed-meshheading:8947043-DNA-Binding Proteins,
pubmed-meshheading:8947043-Etoposide,
pubmed-meshheading:8947043-Gene Expression Regulation,
pubmed-meshheading:8947043-Liver,
pubmed-meshheading:8947043-Mice,
pubmed-meshheading:8947043-Mutation,
pubmed-meshheading:8947043-Phosphorylation,
pubmed-meshheading:8947043-Proto-Oncogene Proteins c-met,
pubmed-meshheading:8947043-Receptor Protein-Tyrosine Kinases,
pubmed-meshheading:8947043-Receptors, Platelet-Derived Growth Factor,
pubmed-meshheading:8947043-Staurosporine,
pubmed-meshheading:8947043-Transcription Factors,
pubmed-meshheading:8947043-Transfection,
pubmed-meshheading:8947043-Tyrosine
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pubmed:year |
1996
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pubmed:articleTitle |
HGF receptor associates with the anti-apoptotic protein BAG-1 and prevents cell death.
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