Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
22
pubmed:dateCreated
1997-1-9
pubmed:abstractText
The vpr genes of human and simian immunodeficiency viruses (HIV/SIV) encode proteins which are packaged in the virus particle. HIV-1 Vpr has been shown to mediate the nuclear import of viral reverse transcription complexes in non-dividing target cells (e.g. terminally differentiated macrophages), and to alter the cell cycle and proliferation status of the infected host cell. Members of the HIV-2/SIV(SM) group encode, in addition to Vpr, a related protein called Vpx. Because these two proteins share considerable sequence similarity, it has been assumed that they also exhibit similar functions. Here, we report that the functions of Vpr and Vpx are distinct and non-redundant, although both proteins are components of the HIV-2/SIV(SM) virion and reverse transcription complex. Characterizing SIV(SM) proviruses defective in one or both genes, we found that Vpx is both necessary and sufficient for the nuclear import of the viral reverse transcription complex. In contrast, Vpr, but not Vpx, inhibited the progression of infected host cells from the G2 to the M phase of the cell cycle. Thus, two independent functions of the HIV-1 Vpr protein are encoded by separate genes in HIV-2/SIV(SM). This segregation is consistent with the conservation of these genes in HIV-2/SIV(SM) evolution, and underscores the importance of both nuclear transport and cell cycle arrest functions in primate lentivirus biology.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/8947037-1324171, http://linkedlifedata.com/resource/pubmed/commentcorrection/8947037-1378513, http://linkedlifedata.com/resource/pubmed/commentcorrection/8947037-1378514, http://linkedlifedata.com/resource/pubmed/commentcorrection/8947037-1404605, http://linkedlifedata.com/resource/pubmed/commentcorrection/8947037-1571197, http://linkedlifedata.com/resource/pubmed/commentcorrection/8947037-1631159, http://linkedlifedata.com/resource/pubmed/commentcorrection/8947037-1711254, http://linkedlifedata.com/resource/pubmed/commentcorrection/8947037-1716442, http://linkedlifedata.com/resource/pubmed/commentcorrection/8947037-1727486, http://linkedlifedata.com/resource/pubmed/commentcorrection/8947037-1971917, http://linkedlifedata.com/resource/pubmed/commentcorrection/8947037-2014052, http://linkedlifedata.com/resource/pubmed/commentcorrection/8947037-2145513, http://linkedlifedata.com/resource/pubmed/commentcorrection/8947037-2668735, http://linkedlifedata.com/resource/pubmed/commentcorrection/8947037-2788224, http://linkedlifedata.com/resource/pubmed/commentcorrection/8947037-2966682, http://linkedlifedata.com/resource/pubmed/commentcorrection/8947037-3095925, http://linkedlifedata.com/resource/pubmed/commentcorrection/8947037-7474080, http://linkedlifedata.com/resource/pubmed/commentcorrection/8947037-7474100, http://linkedlifedata.com/resource/pubmed/commentcorrection/8947037-7531918, http://linkedlifedata.com/resource/pubmed/commentcorrection/8947037-7609047, http://linkedlifedata.com/resource/pubmed/commentcorrection/8947037-7628010, http://linkedlifedata.com/resource/pubmed/commentcorrection/8947037-7666531, http://linkedlifedata.com/resource/pubmed/commentcorrection/8947037-7687060, http://linkedlifedata.com/resource/pubmed/commentcorrection/8947037-7786585, http://linkedlifedata.com/resource/pubmed/commentcorrection/8947037-7815556, http://linkedlifedata.com/resource/pubmed/commentcorrection/8947037-7831833, http://linkedlifedata.com/resource/pubmed/commentcorrection/8947037-7859280, http://linkedlifedata.com/resource/pubmed/commentcorrection/8947037-7884883, http://linkedlifedata.com/resource/pubmed/commentcorrection/8947037-7933064, http://linkedlifedata.com/resource/pubmed/commentcorrection/8947037-7933127, http://linkedlifedata.com/resource/pubmed/commentcorrection/8947037-8041734, http://linkedlifedata.com/resource/pubmed/commentcorrection/8947037-8041786, http://linkedlifedata.com/resource/pubmed/commentcorrection/8947037-8083957, http://linkedlifedata.com/resource/pubmed/commentcorrection/8947037-8105392, http://linkedlifedata.com/resource/pubmed/commentcorrection/8947037-8124721, http://linkedlifedata.com/resource/pubmed/commentcorrection/8947037-8178448, http://linkedlifedata.com/resource/pubmed/commentcorrection/8947037-8230445, http://linkedlifedata.com/resource/pubmed/commentcorrection/8947037-8411357, http://linkedlifedata.com/resource/pubmed/commentcorrection/8947037-8438567, http://linkedlifedata.com/resource/pubmed/commentcorrection/8947037-8440020, http://linkedlifedata.com/resource/pubmed/commentcorrection/8947037-8503191, http://linkedlifedata.com/resource/pubmed/commentcorrection/8947037-8552640, http://linkedlifedata.com/resource/pubmed/commentcorrection/8947037-8615019, http://linkedlifedata.com/resource/pubmed/commentcorrection/8947037-8642659, http://linkedlifedata.com/resource/pubmed/commentcorrection/8947037-8642681
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0261-4189
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
6155-65
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
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