|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
12
|
|
pubmed:dateCreated |
1997-1-7
|
|
pubmed:databankReference |
|
|
pubmed:abstractText |
The Dunning rat prostatic carcinoma is a model system where cell motility closely correlates with the metastatic phenotype. We have identified a novel gene, upregulated in the highly motile and metastatic Dunning cancer cell lines, that represents a new member of the thymosin-beta family, thymosin beta 15. Transfection of antisense thymosin beta 15 constructs into rat prostatic carcinoma cells demonstrates that this molecule positively regulates cell motility, a critical component of the metastatic pathway. Thymosin beta 15 levels are elevated in human prostate cancer and correlate positively with the Gleason tumor grade. Thymosin beta 15 may represent a potential new biochemical marker for human prostate cancer progression.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Actins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Antisense,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Thymosin,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological,
http://linkedlifedata.com/resource/pubmed/chemical/thymosin beta(15), rat
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
1078-8956
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
2
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1322-8
|
|
pubmed:dateRevised |
2008-1-3
|
|
pubmed:meshHeading |
pubmed-meshheading:8946830-Actins,
pubmed-meshheading:8946830-Amino Acid Sequence,
pubmed-meshheading:8946830-Animals,
pubmed-meshheading:8946830-Base Sequence,
pubmed-meshheading:8946830-Carcinoma,
pubmed-meshheading:8946830-Cell Movement,
pubmed-meshheading:8946830-Cloning, Molecular,
pubmed-meshheading:8946830-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:8946830-Humans,
pubmed-meshheading:8946830-Hyperplasia,
pubmed-meshheading:8946830-Male,
pubmed-meshheading:8946830-Molecular Sequence Data,
pubmed-meshheading:8946830-Neoplasm Metastasis,
pubmed-meshheading:8946830-Organ Specificity,
pubmed-meshheading:8946830-Prostate,
pubmed-meshheading:8946830-Prostatic Neoplasms,
pubmed-meshheading:8946830-RNA, Antisense,
pubmed-meshheading:8946830-RNA, Messenger,
pubmed-meshheading:8946830-RNA, Neoplasm,
pubmed-meshheading:8946830-Rats,
pubmed-meshheading:8946830-Recombinant Fusion Proteins,
pubmed-meshheading:8946830-Thymosin,
pubmed-meshheading:8946830-Tumor Cells, Cultured,
pubmed-meshheading:8946830-Tumor Markers, Biological
|
|
pubmed:year |
1996
|
|
pubmed:articleTitle |
Thymosin beta 15: a novel regulator of tumor cell motility upregulated in metastatic prostate cancer.
|
|
pubmed:affiliation |
Department of Surgery and Cell Biology, Harvard Medical School, Children's Hospital, Boston, Massachusetts 02115, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|
