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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
1997-4-4
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pubmed:abstractText |
Splenic blood-volume changes to norepinephrine were determined in the anesthetized cat by recording the integral of the difference between splenic arterial flow and splenic venous flow (flow-differential technique) with ultrasonic transit-time flowmeters, and the changes recorded with this technique were compared with those recorded with an independent technique, the gravimetric method. Norepinephrine (0.003-0.3 microgram/min/kg of body weight) induced dose-related decreases in splenic volume, and the values recorded by the flow-differential technique were not significantly different from those recorded with the gravimetric technique. The values recorded by the two methods were highly correlated (r = 0.86). The slope of the line plotting the relation between the two methods was close to unity (0.97 +/- 0.12), and the intercept of the line was close to zero (-0.46 +/- 1.6 ml). The results suggest that the recording of the flow differential between splenic arterial flow and splenic venous flow with ultrasonic transit time flowmeters is a valid method for the recording of splenic blood-volume changes to vasoactive agents.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Nov
|
pubmed:issn |
0160-2446
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
28
|
pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
605-10
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8945672-Animals,
pubmed-meshheading:8945672-Blood Flow Velocity,
pubmed-meshheading:8945672-Blood Pressure,
pubmed-meshheading:8945672-Blood Volume,
pubmed-meshheading:8945672-Cats,
pubmed-meshheading:8945672-Dose-Response Relationship, Drug,
pubmed-meshheading:8945672-Female,
pubmed-meshheading:8945672-Male,
pubmed-meshheading:8945672-Norepinephrine,
pubmed-meshheading:8945672-Regional Blood Flow,
pubmed-meshheading:8945672-Rheology,
pubmed-meshheading:8945672-Spleen,
pubmed-meshheading:8945672-Ultrasonography, Doppler,
pubmed-meshheading:8945672-Vasoconstrictor Agents
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pubmed:year |
1996
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pubmed:articleTitle |
Validation of a flow-differential technique for the recording of splenic blood-volume changes to vasoactive agents.
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pubmed:affiliation |
Department of Pharmacology, Faculty of Medicine, University of Saskatchewan, Saskatoon, Canada.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|