Linked Life Data

8944700

Source:http://linkedlifedata.com/resource/pubmed/id/8944700

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5 Pt 1
pubmed:dateCreated
1997-1-9
pubmed:abstractText
The roles of 5-hydroxytryptamine3 (5-HT3), 5-HT4, and nicotinic receptors in the peristaltic reflex were investigated in isolated segments of guinea pig distal colon. The reflex assessed by measuring the propulsion of solid pellets, was affected neither by 5-HT3-selective antagonists (ondansetron granisetron) nor by 5-HT4-selective antagonists (SDZ-205-557, GR-113808A, SB-204070) applied individually (1.0 microM); nevertheless, the reflex was inhibited by combining these antagonists or by applying a 5-HT3/5-HT4 dual antagonist (FK-1052). Hexamethonium abolished the peristaltic reflex at 100 microM, but not at 10-32 microM. In contrast, the peristaltic reflex was inhibited when hexamethonium (32 microM was combined with either a 5-HT3- or 5-HT4-selective antagonist (1.0 microM). These observations suggest that 5-HT3, 5-HT4, and nicotinic receptors participate in the initiation and/or propagation of the peristaltic reflex. The data are consistent with the idea that these receptors are arranged in parallel in the neural pathways that mediate the peristaltic reflex in the distal colon.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0002-9513
pubmed:author
pubmed:issnType
Print
pubmed:volume
271
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
G849-57
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Participation of 5-HT3, 5-HT4, and nicotinic receptors in the peristaltic reflex of guinea pig distal colon.
pubmed:affiliation
Department of Anatomy and Cell Biology, College of Physicians and Surgeons, Columbia University, New York 10032, USA.
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't