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| pubmed-article:8943412 | lifeskim:mentions | umls-concept:C0023281 | lld:lifeskim |
| pubmed-article:8943412 | lifeskim:mentions | umls-concept:C0003320 | lld:lifeskim |
| pubmed-article:8943412 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:8943412 | lifeskim:mentions | umls-concept:C0301872 | lld:lifeskim |
| pubmed-article:8943412 | lifeskim:mentions | umls-concept:C0009017 | lld:lifeskim |
| pubmed-article:8943412 | lifeskim:mentions | umls-concept:C0023276 | lld:lifeskim |
| pubmed-article:8943412 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:8943412 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:8943412 | lifeskim:mentions | umls-concept:C1517004 | lld:lifeskim |
| pubmed-article:8943412 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:8943412 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:8943412 | pubmed:dateCreated | 1996-12-27 | lld:pubmed |
| pubmed-article:8943412 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8943412 | pubmed:abstractText | BALB/c mice are highly susceptible to infection with the protozoan parasite Leishmania major. This susceptibility has been attributed, in part, to the expansion of parasite-specific CD4+ Th2 cells that antagonize Th1 responses and promote humoral immunity. In the present study, we have utilized sera from L. major-infected BALB/c mice to screen an L. major amastigote cDNA expression library. One of the clones detected encodes a novel Ag designated as L. major stress-inducible 1 (LmSTI1). LmSTI1 contains six copies of the tetratricopeptide consensus motif and is highly related to a family of stress-inducible proteins that is conserved from yeast to humans. Sera from L. major-infected BALB/c mice have LmSTI1-specific Ab titers in excess of 1:200,000, comprised predominantly of IgG1, IgG2A, and IgG2B isotypes. Recombinant LmSTI1 protein elicited strong proliferative responses from draining lymph node cells of L. major-infected BALB/c mice at both early (10 days) and late (28 days) stages of infection and elicited production of high levels of IFN-gamma and low levels of IL-4. In contrast, soluble leishmanial lysate elicited high levels of IL-4 and low IFN-gamma production. Thus, we have identified an Ag of Leishmania capable of eliciting a mixed cellular response that is skewed toward a Th1 phenotype in susceptible BALB/c mice with advanced infections. In addition, analyses of sera from human patients with cutaneous, visceral, and post-kala azar visceral leishmaniasis indicated that a majority of individuals from all three clinical groups mounted strong humoral responses against LmSTI1. | lld:pubmed |
| pubmed-article:8943412 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8943412 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8943412 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8943412 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:8943412 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8943412 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8943412 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8943412 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:8943412 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:8943412 | pubmed:author | pubmed-author:Campos-NetoAA | lld:pubmed |
| pubmed-article:8943412 | pubmed:author | pubmed-author:ReedS GSG | lld:pubmed |
| pubmed-article:8943412 | pubmed:author | pubmed-author:WebbJ RJR | lld:pubmed |
| pubmed-article:8943412 | pubmed:author | pubmed-author:KaufmannDD | lld:pubmed |
| pubmed-article:8943412 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8943412 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:8943412 | pubmed:volume | 157 | lld:pubmed |
| pubmed-article:8943412 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8943412 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8943412 | pubmed:pagination | 5034-41 | lld:pubmed |
| pubmed-article:8943412 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:8943412 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8943412 | pubmed:articleTitle | Molecular cloning of a novel protein antigen of Leishmania major that elicits a potent immune response in experimental murine leishmaniasis. | lld:pubmed |
| pubmed-article:8943412 | pubmed:affiliation | Infectious Disease Research Institute, Seattle, WA 98104, USA. | lld:pubmed |
| pubmed-article:8943412 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8943412 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:8943412 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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