Linked Life Data

8943406

Source:http://linkedlifedata.com/resource/pubmed/id/8943406

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1996-12-27
pubmed:abstractText
We have investigated the effects of glycoinositolphospholipid (GIPL) purified from Trypanosoma cruzi on murine B cell activation. The GIPL neither stimulated any proliferative response by itself, nor affected the blastogenesis induced by surface IgD cross-linking or LPS. On the other hand, the GIPL significantly stimulated both low and high density B cells to secrete IgM in vitro. The GIPL induced B cells to produce IgM when added in the presence of either the surface Ig cross-linker, anti-delta-dextran, or a combination of IL-4 and IL-5. The T. cruzi-derived GIPL also stimulated Ig class switch to IgG1 in cultures stimulated with GIPL, IL-4, and IL-5. The IgG1 secretion was comparable to that induced by LPS plus IL-4. Production of IgG3 was also detected and the GIPL also potentiated the IgG3 production induced by LPS. The stimulatory effect of the T. cruzi-derived GIPL was mediated mainly by its oligosaccharide moiety. This isolated fraction induced a potent IgM secretory response, compared with a much lower response induced by the isolated GIPL ceramide. Taken together, our data suggest that the stimulatory effect of the T. cruzi-derived GIPL on B cell activation could play a role on the conspicuous Ig production observed during infection of the host with T. cruzi.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0022-1767
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
157
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4996-5001
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Glycoinositolphospholipids purified from Trypanosoma cruzi stimulate Ig production in vitro.
pubmed:affiliation
Department of Immunology, Federal University of Rio de Janeiro, Brazil.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't