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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
1997-1-31
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pubmed:databankReference |
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pubmed:abstractText |
We have shown previously that a GC-rich element (GGGGCGGGGTGGGGGG) conferring epidermal growth factor (EGF) responsiveness to the human gastrin promoter binds Sp1 and additional undefined complexes. A rat GH4 cell line expression library was screened by using a multimer of the gastrin EGF response element, and three overlapping cDNA clones were identified. The full-length rat cDNA encoded an 89-kDa zinc finger protein (ZBP-89) that was 89% identical to a 49-kDa human factor, ht(beta), that binds a GTGGG/CACCC element in T-cell receptor promoters. The conservation of amino acids between the zinc fingers indicates that ZBP-89 is a member of the C2H2 zinc finger family subclass typified by the Drosophila Krüppel protein. ZBP-89 is ubiquitously expressed in normal adult tissues. It binds specifically to the gastrin EGF response element and inhibits EGF induction of the gastrin promoter. Collectively, these results demonstrate that ZBP-89 functions as a repressor of basal and inducible expression of the gastrin gene.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8943318-1282800,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8943318-1323141,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8943318-1406677,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8943318-1502203,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8943318-1569959,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8943318-1654597,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8943318-1664152,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8943318-1852137,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8943318-1881892,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8943318-1922363,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8943318-1946370,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8943318-2017173,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8943318-2026603,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8943318-2105456,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8943318-2181288,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8943318-2187875,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8943318-2563673,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8943318-2569362,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8943318-2572326,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8943318-2698648,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8943318-2771660,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8943318-2964277,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8943318-3127059,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8943318-3356689,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8943318-6336642,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8943318-7565752,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8943318-7573458,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8943318-7682653,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8943318-7721790,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8943318-7753175,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8943318-7890725,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8943318-7890769,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8943318-7969179,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8943318-8114720,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8943318-8294480,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8943318-8317848,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8943318-8355710,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8943318-8392056,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8943318-942051
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0270-7306
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6644-53
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8943318-Amino Acid Sequence,
pubmed-meshheading:8943318-Animals,
pubmed-meshheading:8943318-Base Sequence,
pubmed-meshheading:8943318-Cell Line,
pubmed-meshheading:8943318-DNA-Binding Proteins,
pubmed-meshheading:8943318-Epidermal Growth Factor,
pubmed-meshheading:8943318-Gastrins,
pubmed-meshheading:8943318-Gene Expression Regulation,
pubmed-meshheading:8943318-Humans,
pubmed-meshheading:8943318-Kruppel-Like Transcription Factors,
pubmed-meshheading:8943318-Molecular Sequence Data,
pubmed-meshheading:8943318-Promoter Regions, Genetic,
pubmed-meshheading:8943318-Rats,
pubmed-meshheading:8943318-Repressor Proteins,
pubmed-meshheading:8943318-Transcription Factors,
pubmed-meshheading:8943318-Zinc Fingers
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pubmed:year |
1996
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pubmed:articleTitle |
ZBP-89, a Krüppel-like zinc finger protein, inhibits epidermal growth factor induction of the gastrin promoter.
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pubmed:affiliation |
Department of Internal Medicine, University of Michigan, Ann Arbor 48109, USA. merchanj@umich.edu
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