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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
50
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pubmed:dateCreated |
1997-1-17
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pubmed:abstractText |
The three-dimensional structure of human decorin, a secreted proteoglycan involved in the regulation of collagen fibrillogenesis and cellular growth, has been modeled based on the crystal structure of the porcine ribonuclease inhibitor. Both proteins contain leucine-rich repeats and share 18% identical residues. This model structure of decorin has an arch shape with the single glycosaminoglycan chain and the three N-linked oligosaccharides located on the same side of the molecule. Decorin was modeled as binding to a polar sequence of collagen type I found in the d band. The inner concave surface is the appropriate size and shape to accommodate only one collagen triple helix of approximately 3 nm in length. The binding of one collagen triple helix to decorin is proposed to play a major role in the formation of the staggered arrangement of collagen molecules within the microfibrils by preventing lateral fusion of collagen molecules.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0021-9258
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
13
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pubmed:volume |
271
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
31767-70
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:8943211-Amino Acid Sequence,
pubmed-meshheading:8943211-Animals,
pubmed-meshheading:8943211-Collagen,
pubmed-meshheading:8943211-Decorin,
pubmed-meshheading:8943211-Enzyme Inhibitors,
pubmed-meshheading:8943211-Extracellular Matrix Proteins,
pubmed-meshheading:8943211-Humans,
pubmed-meshheading:8943211-Models, Molecular,
pubmed-meshheading:8943211-Molecular Sequence Data,
pubmed-meshheading:8943211-Protein Conformation,
pubmed-meshheading:8943211-Protein Structure, Secondary,
pubmed-meshheading:8943211-Proteins,
pubmed-meshheading:8943211-Proteoglycans,
pubmed-meshheading:8943211-Sequence Alignment
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pubmed:year |
1996
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pubmed:articleTitle |
Model structure of decorin and implications for collagen fibrillogenesis.
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pubmed:affiliation |
Department of Biochemistry and Molecular Pharmacology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA. Iozzo@lac.jci.tju.edu
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pubmed:publicationType |
Journal Article
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