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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5294
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pubmed:dateCreated |
1997-1-8
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pubmed:abstractText |
A subset of B lymphocytes present primarily in the peritoneal and pleural cavities is defined by the expression of CD5 and is elevated in autoimmune diseases. Upon signaling through membrane immunoglobulin M (mIgM), splenic B lymphocytes (B-2) proliferate, whereas peritoneal B cells (B-1) undergo apoptosis. However, in CD5-deficient mice, B-1 cells responded to mIgM crosslinking by developing a resistance to apoptosis and entering the cell cycle. In wild-type B-1 cells, prevention of association between CD5 and mIgM rescued their growth response to mIgM crosslinking. Thus the B cell receptor-mediated signaling is negatively regulated by CD5 in normal B-1 cells.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
13
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pubmed:volume |
274
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1906-9
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:8943203-Animals,
pubmed-meshheading:8943203-Antigens, CD5,
pubmed-meshheading:8943203-Apoptosis,
pubmed-meshheading:8943203-B-Lymphocyte Subsets,
pubmed-meshheading:8943203-Calcium,
pubmed-meshheading:8943203-Cell Division,
pubmed-meshheading:8943203-Cell Nucleus,
pubmed-meshheading:8943203-Cross-Linking Reagents,
pubmed-meshheading:8943203-Female,
pubmed-meshheading:8943203-Immunoglobulin M,
pubmed-meshheading:8943203-Lymphocyte Activation,
pubmed-meshheading:8943203-Male,
pubmed-meshheading:8943203-Mice,
pubmed-meshheading:8943203-Mice, Inbred C57BL,
pubmed-meshheading:8943203-Mutation,
pubmed-meshheading:8943203-NF-kappa B,
pubmed-meshheading:8943203-Peritoneal Cavity,
pubmed-meshheading:8943203-Receptors, Antigen, B-Cell,
pubmed-meshheading:8943203-Signal Transduction
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pubmed:year |
1996
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pubmed:articleTitle |
CD5-mediated negative regulation of antigen receptor-induced growth signals in B-1 B cells.
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pubmed:affiliation |
Department of Microbiology and Immunology and Center on Aging, University of Kentucky, Lexington, KY 40536, USA. sbonda@pop.uky.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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