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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
24
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pubmed:dateCreated |
1997-1-16
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pubmed:abstractText |
JC virus is activated to replicate in glial cells of many AIDS patients with neurological disorders. In human glial cells, the human immunodeficiency virus 1 (HIV-1) Tat protein activates the major late promoter of JC virus through a Tat-responsive DNA element, termed upTAR, which is a recognition site for cellular Pur alpha, a sequence-specific single-stranded DNA binding protein implicated in cell cycle control of DNA replication and transcription. Tat interacts with two leucine-rich repeats in Pur alpha to form a complex that can be immunoprecipitated from cell extracts. Tat enhances the ability of purified glutathione S-transferase-Pur alpha (GST-Pur alpha) to bind the upTAR element. Tat acts synergistically with Pur alpha, in a cell-cycle-dependent manner, to activate transcription at an upTAR element placed upstream of a heterologous promoter. Since Pur alpha is ubiquitously expressed in human cells and since PUR elements are located near many promoters and origins of replication, the Tat-Pur alpha interaction may be implicated in effects of HIV-1 throughout the full range of HIV-1-infected cells.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Chloramphenicol O-Acetyltransferase,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP Response...,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Gene Products, tat,
http://linkedlifedata.com/resource/pubmed/chemical/Leucine,
http://linkedlifedata.com/resource/pubmed/chemical/PURA protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/tat Gene Products, Human...
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
26
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pubmed:volume |
93
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
14112-7
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pubmed:dateRevised |
2008-11-20
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pubmed:meshHeading |
pubmed-meshheading:8943069-Amino Acid Sequence,
pubmed-meshheading:8943069-Binding Sites,
pubmed-meshheading:8943069-Cell Cycle,
pubmed-meshheading:8943069-Cell Line,
pubmed-meshheading:8943069-Chloramphenicol O-Acetyltransferase,
pubmed-meshheading:8943069-Cyclic AMP Response Element-Binding Protein,
pubmed-meshheading:8943069-DNA Replication,
pubmed-meshheading:8943069-DNA-Binding Proteins,
pubmed-meshheading:8943069-Gene Products, tat,
pubmed-meshheading:8943069-Glioblastoma,
pubmed-meshheading:8943069-HIV-1,
pubmed-meshheading:8943069-Humans,
pubmed-meshheading:8943069-JC Virus,
pubmed-meshheading:8943069-Leucine,
pubmed-meshheading:8943069-Molecular Sequence Data,
pubmed-meshheading:8943069-Neuroglia,
pubmed-meshheading:8943069-Protein Binding,
pubmed-meshheading:8943069-Recombinant Proteins,
pubmed-meshheading:8943069-Sequence Deletion,
pubmed-meshheading:8943069-Sequence Homology, Amino Acid,
pubmed-meshheading:8943069-Transcription, Genetic,
pubmed-meshheading:8943069-Transcription Factors,
pubmed-meshheading:8943069-Transfection,
pubmed-meshheading:8943069-Virus Activation,
pubmed-meshheading:8943069-Virus Replication,
pubmed-meshheading:8943069-tat Gene Products, Human Immunodeficiency Virus
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pubmed:year |
1996
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pubmed:articleTitle |
Activation of the JC virus Tat-responsive transcriptional control element by association of the Tat protein of human immunodeficiency virus 1 with cellular protein Pur alpha.
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pubmed:affiliation |
Department of Pathology, Mount Sinai School of Medicine, New York, NY 10029, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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