Linked Life Data

8940258

Source:http://linkedlifedata.com/resource/pubmed/id/8940258

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1997-1-23
pubmed:abstractText
The effects of transforming growth factor-beta1 (TGFbeta) on two human neuroblastoma cell lines, LAN-5 and SK-N-AS, and one human glioblastoma cell line, GL15, were evaluated. Of the three cultures, only two, SK-N-AS and GL15, had a complete response to TGFbeta, with induction of the following effects: (i) inhibition of cell proliferation; (ii) up-regulation of the extracellular matrix glycoprotein fibronectin, together with down-regulation of the VLA5 integrin receptor; (iii) up-regulation of histotype-specific cytoskeletal intermediate filaments (neurofilaments for neuroblastoma and GFAP for glioblastoma); and (iv) increase in the glycoprotein CD44, only in SK-N-AS. In the third cell line, neuroblastoma LAN-5, the effects exerted by TGFbeta consisted only of (i) neurofilament increase and (ii) morphological differentiation. The TGFbeta receptor pattern was different in each culture: SK-N-AS expressed low rates of type I and type II receptors and high rates of type III receptor; LAN-5 expressed high rates of type I, low rates of type II, and no type III; GL15 expressed high rates of all three receptors. These data suggest that TGFbeta can induce a histotype-specific cell maturation and that the neuroblastoma expressing low type II and at the same time lacking type III receptor responds only partially to TGFbeta, with induction of neural differentiation but without inhibition of cell growth.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0014-4827
pubmed:author
pubmed:issnType
Print
pubmed:day
25
pubmed:volume
229
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
147-54
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:8940258-Antigens, CD44, pubmed-meshheading:8940258-Cell Differentiation, pubmed-meshheading:8940258-Cell Division, pubmed-meshheading:8940258-Culture Media, Conditioned, pubmed-meshheading:8940258-Fibronectins, pubmed-meshheading:8940258-Gene Expression Regulation, pubmed-meshheading:8940258-Glial Fibrillary Acidic Protein, pubmed-meshheading:8940258-Glioma, pubmed-meshheading:8940258-Humans, pubmed-meshheading:8940258-Neuroblastoma, pubmed-meshheading:8940258-Neurofilament Proteins, pubmed-meshheading:8940258-Neurons, pubmed-meshheading:8940258-Phenotype, pubmed-meshheading:8940258-Receptors, Fibronectin, pubmed-meshheading:8940258-Receptors, Transforming Growth Factor beta, pubmed-meshheading:8940258-Transforming Growth Factor beta, pubmed-meshheading:8940258-Tumor Cells, Cultured
pubmed:year
1996
pubmed:articleTitle
Transforming growth factor beta regulates differentiation and proliferation of human neuroblastoma.
pubmed:affiliation
Experimental Medicine and Pathology Department, University La Sapienza, Rome, Italy.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't