Linked Life Data

8937517

Source:http://linkedlifedata.com/resource/pubmed/id/8937517

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1997-1-2
pubmed:abstractText
Recent immunohistochemical observations on atherosclerotic lesions in human aortas and coronary arteries have revealed that these lesions contain mast cells. Mast cells, better known for their actions in allergic reactions of skin and mucosal surfaces, are filled with cytoplasmic secretory granules that contain histamine, heparin and neutral proteases, notably chymase. When activated these cells degranulate, and in this way may influence lipoprotein metabolism in their immediate environment. Indeed, animal studies have suggested that exocytosed mast cell granules may carry LDL into peritoneal macrophages, and so induce their conversion into foam cells. With immunoelectron microscopic techniques, evidence was obtained suggesting that such a 'granule carrier pathway' may operate in vivo in the human arterial intima.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0957-9672
pubmed:author
pubmed:issnType
Print
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
281-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Mast cells in human fatty streaks and atheromas: implications for intimal lipid accumulation.
pubmed:affiliation
Wihuri Research Institute, Helsinki, Finland.
pubmed:publicationType
Journal Article, Review