Linked Life Data

8936999

Source:http://linkedlifedata.com/resource/pubmed/id/8936999

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1996-12-24
pubmed:abstractText
Mutations of one p 53 allele and LOH occur in advanced lung cancers, but in early lung cancer these things were not known well. To make clear carcinogenesis of lung cancer, it is important to study p 53 alterations in early lung cancers. We studied them in 29 roentgenographically occult lung cancers by means of PCR-SSCP and microsatellite marker. PCR-SSCP was performed for exon 7 of the p 53 gene. LOH was found in 6 cases and point mutation was found in 2 cases (codon 234 T-A transversion, codon 245 G-T transition). Frequency of LOH and point mutations was lower than in the cases of advanced lung cancers. These things suggested the clonal expansion of aberrant p 53 gene occurred in the course of cancer development (i.e., roentgenographically occult lung cancer to advanced lung cancer).
pubmed:language
jpn
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0021-5252
pubmed:author
pubmed:issnType
Print
pubmed:volume
49
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
990-3
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
[Aberrations of the p 53 gene in roentgenographically occult squamous cell carcinoma of the lung].
pubmed:affiliation
Department of Thoracic Surgery, Aging and Cancer, Tohoku University, Sendai, Japan.
pubmed:publicationType
Journal Article, English Abstract