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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1977-10-31
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pubmed:abstractText |
An equimolar mixture of a xanthurenic acid-insulin complex and ZnSO4 was separated into an insulin peak and a peak containing xanthurenic acid (XA) and Zn by Sephadex G-75 column chromatograpy. XA and di-[L-histidino]-zinc (II) readily combined to produce di-[L-histidino]-di-xanthurenato zinc (II) (His2-Zn2+-XA2). By increase in the concentration of Zn2+ ions, XA was removed from di-[L-histidino]-di-xanthurenato zinc (II) (His2-Zn2+-XA2) as XA-Zn2+. The XA-insulin complex showed dcreased relative intensity of fluorescence compared with the Zn-insulin when excited at a wavelength of 284 nm. The difference spectrum between native Zn-insulin and XA-insulin complexes showed a slight red shift. A diffference in the CD spectrum between native Zn-insulin and XA-insulin complexes was observed.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Dipeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Histidine,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Xanthurenates,
http://linkedlifedata.com/resource/pubmed/chemical/Zinc
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0021-924X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
82
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
67-72
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:893387-Binding Sites,
pubmed-meshheading:893387-Chromatography, Gel,
pubmed-meshheading:893387-Circular Dichroism,
pubmed-meshheading:893387-Dipeptides,
pubmed-meshheading:893387-Histidine,
pubmed-meshheading:893387-Insulin,
pubmed-meshheading:893387-Protein Binding,
pubmed-meshheading:893387-Spectrophotometry,
pubmed-meshheading:893387-Xanthurenates,
pubmed-meshheading:893387-Zinc
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pubmed:year |
1977
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pubmed:articleTitle |
Interaction between xanthurenic acid-insulin complex and zinc ions.
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pubmed:publicationType |
Journal Article
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