8933039

Source:http://linkedlifedata.com/resource/pubmed/id/8933039

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0001554, umls-concept:C0011900, umls-concept:C0221052, umls-concept:C1273870
pubmed:dateCreated	1997-2-21
pubmed:abstractText	Chronic beryllium disease is predominantly a pulmonary granulomatosis that was originally described in 1946. Symptoms usually include dyspnea and cough. Fever, anorexia, and weight loss are common. Skin lesions are the most common extrathoracic manifestation. Granulomatous hepatitis, hypercalcemia, and kidney stones can also occur. Radiographic and physiologic abnormalities are similar to those in sarcoidosis. While traditionally the pathologic changes included granulomas and cellular interstitial changes, the hallmark of the disease today is the well-formed granuloma. Immunologic studies have demonstrated a cell-mediated response to beryllium that is due to an accumulation of CD4+ T cells at the site of disease activity. Diagnosis depends on the demonstration of pathologic changes (i.e., granuloma) and evidence that the granuloma was caused by a hypersensitivity to beryllium (i.e., positive lung proliferative response to beryllium). Using these criteria, the diagnosis of chronic beryllium disease can now be made before the onset of clinical symptoms. Whether, with early diagnosis, the natural course of this condition will be the same as when it was traditionally diagnosed is not known. Currently, corticosteroids are used to treat patients with significant symptoms or evidence of progressive disease.
pubmed:commentsCorrections	http://linkedlifedata.com/resource/pubmed/commentcorrection/8933039-14867858, http://linkedlifedata.com/resource/pubmed/commentcorrection/8933039-2469014, http://linkedlifedata.com/resource/pubmed/commentcorrection/8933039-2602683, http://linkedlifedata.com/resource/pubmed/commentcorrection/8933039-3277503, http://linkedlifedata.com/resource/pubmed/commentcorrection/8933039-3282464, http://linkedlifedata.com/resource/pubmed/commentcorrection/8933039-3492158, http://linkedlifedata.com/resource/pubmed/commentcorrection/8933039-3575713, http://linkedlifedata.com/resource/pubmed/commentcorrection/8933039-4690875, http://linkedlifedata.com/resource/pubmed/commentcorrection/8933039-4717994, http://linkedlifedata.com/resource/pubmed/commentcorrection/8933039-4892951, http://linkedlifedata.com/resource/pubmed/commentcorrection/8933039-5353854, http://linkedlifedata.com/resource/pubmed/commentcorrection/8933039-5521721, http://linkedlifedata.com/resource/pubmed/commentcorrection/8933039-6089376, http://linkedlifedata.com/resource/pubmed/commentcorrection/8933039-7103279, http://linkedlifedata.com/resource/pubmed/commentcorrection/8933039-8025739, http://linkedlifedata.com/resource/pubmed/commentcorrection/8933039-8115636, http://linkedlifedata.com/resource/pubmed/commentcorrection/8933039-8214955, http://linkedlifedata.com/resource/pubmed/commentcorrection/8933039-8455096
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0330411
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	Oct
pubmed:issn	0091-6765
pubmed:author	pubmed-author:RossmanM DMD
pubmed:issnType	Print
pubmed:volume	104 Suppl 5
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	945-7
pubmed:dateRevised	2009-11-18
pubmed:meshHeading	pubmed-meshheading:8933039-Berylliosis, pubmed-meshheading:8933039-Chronic Disease, pubmed-meshheading:8933039-Humans
pubmed:year	1996
pubmed:articleTitle	Chronic beryllium disease: diagnosis and management.
pubmed:affiliation	Pulmonary and Critical Care Division, Hospital of the University of Pennsylvania, Philadelphia 19104-4283, USA. rossmanm@mail.med.upenn.edu
pubmed:publicationType	Journal Article, Review