Linked Life Data

893273

Source:http://linkedlifedata.com/resource/pubmed/id/893273

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1977-10-28
pubmed:abstractText
Anesthesia produced by the intravenous steroid agent, Althesin, was studied in Sprague-Dawley rats with and without high pressure of helium gas up to 100 atmospheres absolute (ATA). There were no cumulative or adaptive changes in Althesin requirement at normal pressures over 6-h periods. However, the apparent potency of the agent was reduced by 43% by the addition of 68 ATA helium. Subanesthetic doses of Althesin protected against the onset of convulsions and coarse tremors associated with the high pressure neurological syndrome. It is concluded that the steroid anesthetics may have a place in human diving technology and that the mechanisms associated with the anesthetic-pressure interactions are consistent with the critical volume or lipid bilayer fluidity hypothesis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0161-7567
pubmed:author
pubmed:issnType
Print
pubmed:volume
43
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
183-8
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1977
pubmed:articleTitle
High pressure and intravenous steroid anesthesia in rats.
pubmed:publicationType
Journal Article