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rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
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|
pubmed:dateCreated |
1997-4-2
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|
pubmed:abstractText |
The direct and indirect inhibitory potential of D-penicillamine toward human neutrophil and synovial fluid gelatinase B, a marker enzyme for disease severity in RA, was investigated. Gelatinase and plasminogen activator activities were assessed by SDS-polyacrylamide gel electrophoresis zymography. D-penicillamine significantly inhibits purified and synovial fluid gelatinase B in vitro at concentrations attainable in vivo and also blocks in vitro plasminogen activation. Protease inhibition may be a mechanism of action for D-penicillamine as DMARD.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jan
|
|
pubmed:issn |
0770-3198
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
15
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
31-4
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:8929772-Anti-Bacterial Agents,
pubmed-meshheading:8929772-Antirheumatic Agents,
pubmed-meshheading:8929772-Arthritis, Rheumatoid,
pubmed-meshheading:8929772-Biological Markers,
pubmed-meshheading:8929772-Collagenases,
pubmed-meshheading:8929772-Dose-Response Relationship, Drug,
pubmed-meshheading:8929772-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:8929772-Endopeptidases,
pubmed-meshheading:8929772-Humans,
pubmed-meshheading:8929772-Matrix Metalloproteinase 9,
pubmed-meshheading:8929772-Minocycline,
pubmed-meshheading:8929772-Penicillamine,
pubmed-meshheading:8929772-Pyridones,
pubmed-meshheading:8929772-Severity of Illness Index,
pubmed-meshheading:8929772-Synovial Fluid
|
|
pubmed:year |
1996
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|
pubmed:articleTitle |
Human gelatinase B, a marker enzyme in rheumatoid arthritis, is inhibited by D-penicillamine: anti-rheumatic activity by protease inhibition.
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|
pubmed:affiliation |
Rega Institute for Medical Research, Leuven, Belgium.
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|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|
