| pubmed-article:8929453 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8929453 | lifeskim:mentions | umls-concept:C0104998 | lld:lifeskim |
| pubmed-article:8929453 | lifeskim:mentions | umls-concept:C0020204 | lld:lifeskim |
| pubmed-article:8929453 | lifeskim:mentions | umls-concept:C0167627 | lld:lifeskim |
| pubmed-article:8929453 | lifeskim:mentions | umls-concept:C0041904 | lld:lifeskim |
| pubmed-article:8929453 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:8929453 | lifeskim:mentions | umls-concept:C1705431 | lld:lifeskim |
| pubmed-article:8929453 | lifeskim:mentions | umls-concept:C0883208 | lld:lifeskim |
| pubmed-article:8929453 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:8929453 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:8929453 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:8929453 | pubmed:dateCreated | 1996-12-23 | lld:pubmed |
| pubmed-article:8929453 | pubmed:abstractText | The upregulation of costimulatory molecules of antigen presenting cells (APC) resulting from interaction with activated T cells was studied in an in vitro system composed of well-characterized murine T hybridomas and B cell lymphomas. Increased B7-1 expression was induced on both MHC-matched and -mismatched (bystander) B lymphoma cells present in cultures of activated T hybridomas. Identical results were obtained with T hybridomas activated by either the appropriate peptide presented by MHC-matched APC or by mitogen stimulation in the absence of MHC/TCR cognate interactions. Soluble factors alone did not lead to upregulation of B7-1; B lymphomas cultured on the opposite side of a transwell membrane from an ongoing T cell stimulation response, or in supernatants of activated T cells, did not exhibit enhanced expression of B7-1. Antibodies to the CD40 ligand (CD40L) of T cells inhibited the increased appearance of B7-1 on B lymphomas. Significant B7-1 upregulation on the population of bystander B cells could be achieved even when they were present at a 10:1 excess over MHC-matched APC. These data indicate that B7-1 upregulation results from contact between bystander B cells and activated T hybridomas in vitro by CD40-CD40L interaction, without the requirement for TCR/MHC interaction. | lld:pubmed |
| pubmed-article:8929453 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8929453 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8929453 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8929453 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8929453 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8929453 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8929453 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8929453 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8929453 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8929453 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:8929453 | pubmed:issn | 0008-8749 | lld:pubmed |
| pubmed-article:8929453 | pubmed:author | pubmed-author:JonesK WKW | lld:pubmed |
| pubmed-article:8929453 | pubmed:author | pubmed-author:HackettC JCJ | lld:pubmed |
| pubmed-article:8929453 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8929453 | pubmed:day | 25 | lld:pubmed |
| pubmed-article:8929453 | pubmed:volume | 174 | lld:pubmed |
| pubmed-article:8929453 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8929453 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8929453 | pubmed:pagination | 42-53 | lld:pubmed |
| pubmed-article:8929453 | pubmed:dateRevised | 2003-11-14 | lld:pubmed |
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| pubmed-article:8929453 | pubmed:meshHeading | pubmed-meshheading:8929453-... | lld:pubmed |
| pubmed-article:8929453 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8929453 | pubmed:articleTitle | Activated T hybridomas induce upregulation of B7-1 on bystander B lymphoma cells by a contact-dependent interaction utilizing CD40 ligand. | lld:pubmed |
| pubmed-article:8929453 | pubmed:affiliation | ImmuLogic Pharmaceutical Corporation, Waltham, Massachusetts 02154, USA. | lld:pubmed |
| pubmed-article:8929453 | pubmed:publicationType | Journal Article | lld:pubmed |
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