Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4 Pt 1
pubmed:dateCreated
1996-11-20
pubmed:abstractText
Recent studies in children suggest that there are age-related differences in the insulin-like growth factor I (IGF-I) response to malnutrition. To extend this observation, immature 4-wk-old male rats were fasted for 3 days, fed ad libitum (control), or fed 60 or 40% of control calories (restricted) and compared with 8-wk-old young adults. Over the 3-wk study period, serum total IGF-I levels of the older rats were stable despite reduced insulin levels, whereas IGF-I increased 2.2-fold in the younger controls. With the 40% diet, younger and older rats changed body weight +1 and -1 body wt/day, respectively (P < 0.0001). The restricted younger animals reduced serum IGF-I IGF binding protein-3, acid-labile subunit, and growth hormone binding protein levels significantly more than the restricted older animals. Fasting decreased most of these parameters by 40%, serum insulin by approximately 80%, and body weight by 9%, regardless of age. We conclude that the suppression of the IGF-I system in response to chronic undernutrition, but not acute fasting, is greater in maturing than young adult rats.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0002-9513
pubmed:author
pubmed:issnType
Print
pubmed:volume
270
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
E646-53
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed-meshheading:8928772-Aging, pubmed-meshheading:8928772-Animals, pubmed-meshheading:8928772-Body Weight, pubmed-meshheading:8928772-Carrier Proteins, pubmed-meshheading:8928772-Chronic Disease, pubmed-meshheading:8928772-Eating, pubmed-meshheading:8928772-Energy Intake, pubmed-meshheading:8928772-Fasting, pubmed-meshheading:8928772-Glycoproteins, pubmed-meshheading:8928772-Health Status, pubmed-meshheading:8928772-Humans, pubmed-meshheading:8928772-Insulin-Like Growth Factor Binding Protein 3, pubmed-meshheading:8928772-Insulin-Like Growth Factor I, pubmed-meshheading:8928772-Liver, pubmed-meshheading:8928772-Male, pubmed-meshheading:8928772-Nutrition Disorders, pubmed-meshheading:8928772-Organ Size, pubmed-meshheading:8928772-RNA, Messenger, pubmed-meshheading:8928772-Rats, pubmed-meshheading:8928772-Rats, Sprague-Dawley, pubmed-meshheading:8928772-Recombinant Proteins
pubmed:year
1996
pubmed:articleTitle
Developmental differences in the IGF-I system response to severe and chronic calorie malnutrition.
pubmed:affiliation
Endocrine Research, Department of Genentech, South San Francisco, California 94080, USA. oster@gene.com
pubmed:publicationType
Journal Article