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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1996-11-20
|
| pubmed:abstractText |
We have previously shown that chronic exposure of plateau-phase C3H 10 T1/2 cells to (60)Co gamma radiation at doses as low as 10 cGy protected the cells against neoplastic transformation by a subsequent large acute radiation exposure. We have also shown that this induced resistance to neoplastic transformation correlated with an increased ability to repair radiation-induced chromosome breaks. We now show that a single exposure of quiescent cells to doses as low as 0.1 cGy also reduces the risk of neoplastic transformation, from the spontaneous level to a rate three- to fourfold below that level. Higher doses, up to 10 cGy at the same dose rate (0.24 cGy/min), did not reduce the neoplastic transformation frequency further. This protective effect was seen only in irradiated cells that were allowed to incubate at 37 degrees C before release from contact inhibition. Cells released into low-density subcultures immediately after irradiation had unchanged neoplastic transformation frequencies. These results demonstrate that low or chronic exposure to radiation can induce processes which protect the cell against naturally occurring as well as radiation-induced alterations that lead to cell transformation. If similar processes are induced in human cells, the results also suggest that a single low dose, at background or occupational exposure levels, may in some circumstances reduce rather than increase cancer risk, a conclusion inconsistent with the linear no-threshold model of cancer risk from radiation.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0033-7587
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
146
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
369-73
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:8927708-Animals,
pubmed-meshheading:8927708-Cell Line,
pubmed-meshheading:8927708-Cell Transformation, Neoplastic,
pubmed-meshheading:8927708-Dose-Response Relationship, Radiation,
pubmed-meshheading:8927708-Gamma Rays,
pubmed-meshheading:8927708-Humans,
pubmed-meshheading:8927708-Interphase,
pubmed-meshheading:8927708-Mice,
pubmed-meshheading:8927708-Neoplasms, Radiation-Induced,
pubmed-meshheading:8927708-Radiation Tolerance,
pubmed-meshheading:8927708-Radiobiology,
pubmed-meshheading:8927708-Risk Factors
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
Low-dose ionizing radiation decreases the frequency of neoplastic transformation to a level below the spontaneous rate in C3H 10T1/2 cells.
|
| pubmed:affiliation |
Radiation Biology and Health Physics Branch, Atomic Energy of Canada Limited, Chalk River Laboratories, Ontario, Canada.
|
| pubmed:publicationType |
Journal Article
|